N-(2-Chloro-6-iodopyridin-3-yl)pivalamide
N-(2-Chloro-6-iodopyridin-3-yl)pivalamide (CAS 1138444-26-4, C10H12ClIN2O, molar mass 338.57 g/mol) is a halogenated pyridine building block carrying differentiated chloro and iodo substituents alongside a pivalamide-protected 3-amino group. It is used principally in pharmaceutical and fine-chemical synthesis as an orthogonally functionalised scaffold for transition-metal cross-coupling and directed C-H functionalisation. Tech Serve Solutions supplies it as a research-grade heterocyclic intermediate to discovery and process laboratories worldwide.
- Synonyms
- N-(2-Chloro-6-iodopyridin-3-yl)pivalamideN-(2-Chloro-6-iodo-3-pyridinyl)-2,2-dimethylpropanamide2,2-Dimethyl-N-(2-chloro-6-iodopyridin-3-yl)propanamideN-(2-Chloro-6-iodopyridin-3-yl)-2,2-dimethylpropanamideCAS 1138444-26-4
Orthogonal cross-coupling scaffold
The more reactive C-I bond and the C-Cl bond allow sequential, selective palladium-catalysed couplings (Suzuki, Negishi, Sonogashira, Stille). This enables chemists to install two different substituents onto the pyridine ring in a controlled, stepwise manner.
Pharmaceutical intermediate
As a substituted aminopyridine, it serves as a building block in medicinal-chemistry programmes and the assembly of more complex heterocyclic drug candidates. It is offered for research and development use.
Directed metalation and C-H functionalisation
The pivalamide acts as a robust directing and protecting group for the 3-amino position, supporting directed ortho-metalation and regioselective functionalisation of the pyridine core.
Heterocyclic library synthesis
The dual halogen handles make the compound a useful node for parallel and combinatorial synthesis, allowing rapid generation of diversified pyridine analogues for screening libraries.
Agrochemical and specialty research
Halogenated pyridines of this type are common intermediates in agrochemical and specialty fine-chemical discovery. Specific end-uses depend on the customer's own synthetic route.
| Molecular weight | 338.57 |
|---|---|
| Empirical formula | C10H12ClIN2O |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-(2-Chloro-6-iodopyridin-3-yl)pivalamide used for?
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It is used mainly as a building block in pharmaceutical and fine-chemical synthesis. Its differentiated chloro and iodo groups support selective, sequential cross-coupling reactions, while the pivalamide protects and directs functionalisation at the 3-amino position, making it valuable for constructing substituted pyridine scaffolds.
What is the CAS number and molecular formula of N-(2-Chloro-6-iodopyridin-3-yl)pivalamide?
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Its CAS number is 1138444-26-4 and its molecular formula is C10H12ClIN2O, with a molecular weight of 338.57 g/mol. It is a halogenated heterocyclic building block belonging to the pyridine class.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound as a research/reagent-grade synthetic intermediate. We do not represent it as USP, BP or EP pharmacopoeial grade. A batch-specific certificate of analysis confirming the actual assay is provided with each consignment on request.
How should N-(2-Chloro-6-iodopyridin-3-yl)pivalamide be handled and stored?
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Handle as a laboratory research chemical using good chemical hygiene: wear suitable gloves, eye protection and a lab coat, avoid dust formation, and work with adequate ventilation. Store tightly closed in a cool, dry, well-ventilated place away from incompatible materials. Always consult our Safety Data Sheet (SDS) before use; we provide a current SDS with every order.
How is N-(2-Chloro-6-iodopyridin-3-yl)pivalamide packed, shipped and exported?
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It is packed in sealed, appropriately labelled containers sized from gram to bulk research quantities, with packaging selected to protect product integrity in transit. As an established exporter, Tech Serve Solutions arranges compliant international documentation and dispatch, accompanied by a certificate of analysis and SDS.
How do I request a sample or a quote?
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Contact Tech Serve Solutions with your required quantity, packaging and destination, and our team will respond with availability, lead time and a formal quotation. Samples can be arranged for evaluation, subject to availability.
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