N-Methyl-o-toluidine
N-Methyl-o-toluidine (CAS: 611-21-2), with the linear formula CH₃C₆H₄NHCH₃ and a molecular weight of 121.18 g/mol, is a key organic building block. This nitrogen compound serves as a versatile reactant in various chemical synthesis processes, particularly in palladium-catalyzed coupling reactions and amination of bromoindazoles. It is supplied by Tech Serve Solutions with an assay of ≥95%.
- IUPAC
- 2,N-Dimethylaniline,2-Methyl-N-methylaniline,N,2-Dimethylbenzenamine,N,2-Dimethylaniline,N,o-Dimethylaniline,N-(2-Methylphenyl)methylamine,N-Methyl-2-methylaniline,N-Methyl-2-methylbenzenamine,N-Methyl-N-(o-tolyl)amine,N-Methyl-o-methylaniline,o,N-Dimethylaniline,Methyl(o-tolyl)amine,NSC 9395
- Synonyms
- 2,N-Dimethylaniline2-Methyl-N-methylanilineN,2-DimethylbenzenamineN,2-DimethylanilineN,o-DimethylanilineN-(2-Methylphenyl)methylamineN-Methyl-2-methylanilineN-Methyl-2-methylbenzenamineN-Methyl-N-(o-tolyl)amineN-Methyl-o-methylanilineo,N-DimethylanilineMethyl(o-tolyl)amineNSC 9395
Palladium-Catalyzed Coupling Reactions
N-Methyl-o-toluidine acts as a reactant in palladium-catalyzed coupling reactions. These reactions are fundamental in organic synthesis for forming carbon-carbon and carbon-heteroatom bonds.
Amination of Bromoindazoles
This compound is employed in the palladium-catalyzed amination of bromoindazoles. This application is crucial for the synthesis of nitrogen-containing heterocyclic compounds, often found in pharmaceuticals.
Organic Synthesis Building Block
As an amine derivative and an aromatic compound, N-Methyl-o-toluidine functions as a valuable building block in the construction of more complex organic molecules for research and development.
| Molecular weight | 121.18 |
|---|---|
| Linear formula | CH3C6H4NHCH3 |
| Assay | ≥95% |
| Boiling point | 177-204 °C/740 mmHg(lit.) |
| Density | 0.981 g/mL at 25 °C(lit.) |
| Application | Reactant for:• Palladium-catalyzed coupling reactions1• Palladium-catalyzed amination of bromoindazoles2 |
Hazard statements
- H301Toxic if swallowed
- H311Toxic in contact with skin
- H331Toxic if inhaled
- H373May cause damage to organs through prolonged exposure
- H412Harmful to aquatic life with long-lasting effects
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P273Avoid release to the environment
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P311Call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 79 °C / 174.2 °F |
| Transport (UN / ADR) | UN 2810 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 23/24/25-33-52/53 |
| Safety statements (S) | 28-36/37-45-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-Methyl-o-toluidine primarily used for?
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N-Methyl-o-toluidine is primarily used as a reactant in palladium-catalyzed coupling reactions, including the amination of bromoindazoles, and serves as a building block in organic synthesis.
What are the CAS number and molecular formula for N-Methyl-o-toluidine?
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The CAS number for N-Methyl-o-toluidine is 611-21-2, and its linear formula is CH₃C₆H₄NHCH₃.
What grade and purity does Tech Serve Solutions supply for N-Methyl-o-toluidine?
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Tech Serve Solutions supplies N-Methyl-o-toluidine with a purity of ≥95%. This is a technical/research grade, and TSS does not represent it as USP, BP, or EP grade.
What are the main safety hazards associated with N-Methyl-o-toluidine?
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N-Methyl-o-toluidine is classified as toxic if swallowed, in contact with skin, or if inhaled (H301-H311-H331). It may also cause damage to organs through prolonged or repeated exposure (H373) and is harmful to aquatic life with long-lasting effects (H412). Handle with appropriate personal protective equipment, including gloves, eyeshields, and a suitable respirator.
How is N-Methyl-o-toluidine typically shipped and exported?
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N-Methyl-o-toluidine is shipped and exported under UN 2810, Hazard Class 6.1, Packing Group III, indicating it is a toxic solid or liquid, n.o.s.
How can I request a quote or sample of N-Methyl-o-toluidine?
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To request a quote or sample, please contact the Tech Serve Solutions sales department via our website or direct inquiry channels.
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