Methanesulfonylacetone

CAS 5000-46-4CH3C(O)CH2SO2CH3Chemical Synthesis

Methanesulfonylacetone (CAS: 5000-46-4) is a chemical compound with the formula CH3C(O)CH2SO2CH3 and a molecular weight of 136.17 g/mol. This sulfone derivative serves as a versatile reactant in organic synthesis. It is particularly useful for the stereoselective preparation of chiral cyclic ketones and the synthesis of poly-substituted pyridines, finding applications in advanced chemical research and development.

IUPAC: 1-(Methylsulfonyl)-2-propanone,NSC 35395
Synonyms: 1-(Methylsulfonyl)-2-propanone

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Methanesulfonylacetone (CH3C(O)CH2SO2CH3) — chemical structure, CAS 5000-46-4; Chemistry, fine chemical supplied by Tech Serve Solutions

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01 /Applications

Stereoselective Synthesis

Methanesulfonylacetone is employed as a key reactant in the stereoselective preparation of chiral cyclic ketones, enabling the synthesis of enantiomerically enriched compounds for pharmaceutical and fine chemical applications.

Heterocycle Synthesis

This compound facilitates the preparation of poly-substituted pyridines and is a valuable component in multicomponent cyclocondensation reactions with aldehydes and aminoazoles, leading to diverse heterocyclic scaffolds.

Friedlander Cyclocondensation

It participates in gold-catalyzed Friedlander cyclocondensation reactions, offering an efficient route to substituted quinolines and related fused heterocyclic systems.

Radical Reactions

Methanesulfonylacetone is utilised in radical homoallylation reactions, contributing to carbon-carbon bond formation and the construction of complex molecular architectures.

02 /Properties

Molecular weight	136.17
Linear formula	CH3C(O)CH2SO2CH3
Application	Reactant for:• Stereoselective preparation of chiral cyclic ketones1• Preparation of poly-substituted pyridines2• Multicomponent cyclocondensation with aldehydes and aminoazoles3• Gold-catalyzed Friedlander cyclocondensation reaction4• Radical homoallylation reactions5
Melting point	48-52 °C(lit.)

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

5000-46-4

MDL number

MFCD00014745

PubChem substance

24878779

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Methanesulfonylacetone used for?

Methanesulfonylacetone is used as a reactant in stereoselective preparation of chiral cyclic ketones, synthesis of poly-substituted pyridines, multicomponent cyclocondensation reactions, gold-catalyzed Friedlander cyclocondensation, and radical homoallylation reactions.

What is the CAS number and chemical formula for Methanesulfonylacetone?

The CAS number is 5000-46-4 and the chemical formula is CH3C(O)CH2SO2CH3.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Methanesulfonylacetone with a purity of 97%. It is supplied as a technical/research grade and is not represented as USP, BP, or EP.

What are the safety considerations when handling Methanesulfonylacetone?

Methanesulfonylacetone is classified under WGK Germany 3. Handling requires appropriate personal protective equipment including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. Refer to the Safety Data Sheet for comprehensive handling information.