Methanesulfonyl chloride
Methanesulfonyl chloride (CAS 124-63-0), with the chemical formula CH3SO2Cl and a molecular weight of 114.55 g/mol, is a key organosulfur compound. It functions as a potent methylating agent, primarily utilised in organic synthesis for the introduction of the mesyl group (-SO2CH3). This reactive intermediate is indispensable for various chemical transformations and the preparation of complex molecules across multiple research and industrial sectors.
- IUPAC
- Mesyl chloride
- Synonyms
- Mesyl chloride
Mesylation Agent in Organic Synthesis
Methanesulfonyl chloride is extensively employed to mesylate alcohols and amines. The resulting mesylates are excellent leaving groups, facilitating nucleophilic substitution reactions crucial for building complex organic structures.
Preparation of Pharmaceutical Intermediates
Its role in introducing the mesyl group makes it valuable in the multi-step synthesis of active pharmaceutical ingredients (APIs) and their intermediates. This allows for strategic modifications to drug molecules.
Protection of Functional Groups
The mesyl group can serve as a protecting group for amines and alcohols during complex synthetic pathways, preventing unwanted reactions and ensuring regioselectivity. It can be selectively removed later in the synthesis.
Reagent in Polymer Chemistry
Methanesulfonyl chloride finds applications in the modification and synthesis of polymers. It can be used to introduce specific functional groups or to alter polymer properties for advanced materials.
| Molecular weight | 114.55 |
|---|---|
| Linear formula | CH3SO2Cl |
| Assay | ≥99.0% (AT) |
| Boiling point | 60 °C/21 mmHg(lit.) |
| Density | 1.48 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.452(lit.)n20/D 1.452 |
Hazard statements
- H300Fatal if swallowed
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P264Wash thoroughly after handling
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P301IF SWALLOWED
- P302IF ON SKIN
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 3246 6.1(8) / PGI |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 24/25-26-34-37 |
| Safety statements (S) | 26-28-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methanesulfonyl chloride used for?
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Methanesulfonyl chloride is a versatile reagent used primarily as a mesylating agent in organic synthesis for the introduction of the mesyl group (-SO2CH3), a key step in creating leaving groups, protecting functional groups, and synthesizing complex organic molecules, including pharmaceutical intermediates.
What is the CAS number and chemical formula for Methanesulfonyl chloride?
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The CAS number for Methanesulfonyl chloride is 124-63-0, and its chemical formula is CH3SO2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Methanesulfonyl chloride with an assay of ≥99.0%. This product is typically supplied as a technical or research grade. We do not represent this product as USP, BP, or EP grade unless explicitly stated.
How should Methanesulfonyl chloride be handled safely?
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Methanesulfonyl chloride is a dangerous substance requiring strict safety protocols. It is acutely toxic if swallowed, in contact with skin, or if inhaled (H300 + H310 + H330) and causes severe skin burns and eye damage (H314). It may also cause respiratory irritation (H335). Always handle with appropriate personal protective equipment, including chemical-resistant gloves, goggles, a face shield, and a suitable respirator, in a well-ventilated area or fume hood.
How is Methanesulfonyl chloride packed and shipped?
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Methanesulfonyl chloride is securely packed in compliance with international transport regulations for hazardous materials. As a globally recognised supplier and exporter, Tech Serve Solutions ensures all shipments adhere to strict safety and regulatory standards, including UN 3246 classification.
How can I request a quote or sample of Methanesulfonyl chloride?
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To request a quote or a sample of Methanesulfonyl chloride, please visit the product page on the Tech Serve Solutions website and use the designated contact form or email our sales department directly.
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