3-(Trifluoroacetyl)indole
3-(Trifluoroacetyl)indole (CAS: 14618-45-2; Formula: C10H6F3NO; Molar Mass: 213.16) is a trifluoromethyl ketone derivative of indole. This compound serves as a valuable building block in organic synthesis. Its primary applications include its use as a reactant in enantioselective synthesis of indoles, preparation of indolecarboxamides, and in the formation of Michael adducts via the Baylis-Hillman reaction.
- IUPAC
- 3-Indolyl trifluoromethyl ketone
Enantioselective Synthesis of Indoles
Utilised as a reactant in palladium-catalyzed kinetic asymmetrical alkylation for the enantioselective synthesis of indole derivatives.
Preparation of N-Pyridinyl Indolecarboxamides
Serves as a reactant in the preparation of N-pyridinyl indolecarboxamides through the amidation of aminopyridine derivatives with indolecarboxylic acid.
Synthesis of Mast Cell Tryptase Inhibitors
Functions as a reactant in the preparation of mast cell tryptase inhibitors, where amidation is a key synthetic step.
Baylis-Hillman Reaction
Acts as a reactant for the formation of Michael adducts, particularly through the Baylis-Hillman reaction.
Indolecarboxamide Formation
A reactant for the preparation of indolecarboxamides via haloform cleavage of (trifluoroacetyl)indole using lithium dialkylamides.
| Molecular weight | 213.16 |
|---|---|
| Empirical formula | C10H6F3NO |
| Assay | 99% |
| Application | • Reactant for enantioselective synthesis of indoles via palladium-catalyzed kinetic asymmetrical alkylation1• Reactant for preparation of N-pyridinyl indolecarboxamides via amidation of aminopyridine derivatives. with indolecarboxylic acid2• Reactant for preparation of mast cell tryptase inhibitors, starting from indoles; using amidation as the key step3• Reactant for formation of Michael adducts via Baylis-Hillman reaction4• Reactant for preparation of indolecarboxamides via haloform cleavage of (trifluoroacetyl)indole with lithium dialkylamides5 |
| Melting point | 211-214 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-(Trifluoroacetyl)indole used for?
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3-(Trifluoroacetyl)indole is used as a reactant in various organic synthesis applications, including enantioselective synthesis of indoles, preparation of indolecarboxamides, and in the Baylis-Hillman reaction.
What are the CAS number and molecular formula for 3-(Trifluoroacetyl)indole?
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The CAS number for 3-(Trifluoroacetyl)indole is 14618-45-2, and its molecular formula is C10H6F3NO.
What grade and purity does Tech Serve Solutions supply for 3-(Trifluoroacetyl)indole?
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Tech Serve Solutions supplies 3-(Trifluoroacetyl)indole with a purity of 99%. We do not represent this product as USP, BP, or EP grade.
How should 3-(Trifluoroacetyl)indole be handled safely?
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3-(Trifluoroacetyl)indole is a warning compound (GHS07) causing skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment including a dust mask (type N95), eyeshields, and gloves in a well-ventilated area. Avoid breathing dust.
Is 3-(Trifluoroacetyl)indole a controlled substance?
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The provided data does not indicate that 3-(Trifluoroacetyl)indole is a controlled substance.
How is 3-(Trifluoroacetyl)indole packed and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. Specific packing and export details are available upon request.
How can I request a sample or quote for 3-(Trifluoroacetyl)indole?
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To request a sample or quote for 3-(Trifluoroacetyl)indole, please contact our sales team through the website or direct inquiry channels.
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