Loperamide hydrochloride

CAS 34552-83-5C29H33ClN2O2 · HClCell Biology

Loperamide hydrochloride (CAS 34552-83-5, C29H33ClN2O2 · HCl) is a synthetic piperidine derivative and opioid agonist. It acts peripherally on the mu-opioid receptors in the myenteric plexus of the large intestine. This action reduces intestinal motility and fluid secretion, making it primarily used for symptomatic treatment of acute and chronic diarrhoea. Available from Tech Serve Solutions, it is supplied for research and development purposes.

IUPAC: 4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutyramide hydrochloride

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Loperamide hydrochloride (C29H33ClN2O2 · HCl) — chemical structure, CAS 34552-83-5; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesCalcium Channel ModulatorsCell BiologyInhibitors and ActivatorsIon ChannelsJohnson & Johnson

01 /Applications

Diarrhoea Management

Loperamide hydrochloride is a well-established active pharmaceutical ingredient for the symptomatic treatment of diarrhoea. It works by decreasing the flow of water and electrolytes into the bowel and by slowing down the movement of the bowel.

Gastrointestinal Motility Inhibition

This compound acts as a peripheral opioid receptor agonist, specifically targeting the myenteric plexus. This mechanism allows for the inhibition of gastrointestinal motility, which is crucial in managing conditions involving excessive bowel movements.

Research and Development

As a bioactive small molecule and approved therapeutic, Loperamide hydrochloride is valuable for pharmacological research. It is used in studies investigating opioid receptor pathways, ion channel modulation, and gastrointestinal physiology.

02 /Properties

Molecular weight	513.50
Empirical formula	C29H33ClN2O2 · HCl

03 /Safety & handling

GHS hazard pictogram: Toxic (GHS06) — Toxic

Danger

Hazard statements

H301Toxic if swallowed

Precautionary statements

P301IF SWALLOWED

Protective equipment	Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Transport (UN / ADR)	UN 2811 6.1 / PGIII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	T
Risk statements (R)	25
Safety statements (S)	45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

34552-83-5

MDL number

MFCD00058581

05 /Additional specifications

Gene Information	human ... OPRM1(4988)

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Loperamide hydrochloride used for?

Loperamide hydrochloride is primarily used for the symptomatic treatment of acute and chronic diarrhoea by reducing intestinal motility and fluid secretion.

What are the CAS number and formula for Loperamide hydrochloride?

The CAS number for Loperamide hydrochloride is 34552-83-5, and its formula is C29H33ClN2O2 · HCl.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Loperamide hydrochloride as a research-grade chemical. We do not claim USP, BP, or EP pharmacopoeia compliance unless explicitly stated in the product specifications. Please refer to the Certificate of Analysis for specific purity details.

How should Loperamide hydrochloride be handled?

Loperamide hydrochloride is classified as acutely toxic if swallowed (H301) and requires careful handling. Appropriate personal protective equipment, including eyeshields, faceshields, gloves, and a P2 respirator, should be used. Refer to the Safety Data Sheet for comprehensive handling instructions.

How is Loperamide hydrochloride shipped?

Loperamide hydrochloride is shipped according to international regulations for hazardous materials. For this product, it is classified under UN 2811, Class 6.1, Packing Group III.

How can I request a quote or sample?

To request a quote or a sample of Loperamide hydrochloride, please contact our sales team through the website or by phone, providing your details and the product CAS number (34552-83-5).