Lometrexol hydrate
Lometrexol hydrate (CAS: 106400-81-1) is a chemical compound with the empirical formula C21H25N5O6 · xH2O. Supplied as a white to light yellow powder, this substance is primarily recognised for its role in research applications, particularly in the study of apoptosis and cell cycle regulation. Its utility extends to being a tool for comparing biological activities, such as that of potent inhibitors of human GARFTase, contributing to advancements in cell biology and signalling research.
- IUPAC
- LY 264618 hydrate,N-[4-[2-[(6R)-2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]benzoyl]-L-glutamic acid hydrate
- Synonyms
- LY 264618 hydrate, N-[4-[2-[(6R)-2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]benzoyl]-L-glutamic acid hydrate
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Apoptosis and Cell Cycle Research
Lometrexol hydrate serves as a valuable reagent in studies investigating apoptosis and cell cycle progression. Its known biological activity makes it suitable for research into cellular mechanisms and signaling pathways.
Enzyme Inhibition Studies
This compound has been utilised to compare the biological activity of potent inhibitors, specifically those targeting human GARFTase. Such applications aid in the development and understanding of enzyme-modulating agents.
Cell Biology Research Tool
As a bioactive small molecule, Lometrexol hydrate is employed in broader cell biology research. It can be used to probe cellular responses and explore various aspects of cell function and signaling.
| Empirical formula | C21H25N5O6 · xH2O |
|---|---|
| Assay | ≥95% (HPLC) |
| Form | powder |
| Colour | white to light yellow |
| Solubility | DMSO: ≥5 mg/mL |
| Storage temperature | 2-8°C |
| Application | Lometrexol hydrate was used to compare the biological activity of potent inhibitor of human GARFTase.1 |
Hazard statements
- H301Toxic if swallowed
Precautionary statements
- P301IF SWALLOWED
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25 |
| Safety statements (S) | 45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Lometrexol hydrate used for?
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Lometrexol hydrate is used in research, particularly for studying apoptosis and cell cycle regulation, and for comparing the biological activity of enzyme inhibitors such as human GARFTase inhibitors.
What are the CAS number and formula for Lometrexol hydrate?
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The CAS number for the anhydrous form is 106400-81-1. The empirical formula is C21H25N5O6 · xH2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Lometrexol hydrate with an assay of ≥95% (HPLC). This product is suitable for research and technical applications; TSS does not represent it as USP, BP, or EP grade.
How should Lometrexol hydrate be handled and stored?
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Lometrexol hydrate is classified as dangerous and toxic if swallowed (H301). Handle with appropriate personal protective equipment in a well-ventilated area. Store refrigerated at 2-8°C.
Is Lometrexol hydrate a controlled substance?
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The provided data does not indicate that Lometrexol hydrate is a controlled substance. It is classified under GHS06 with a Danger signal word.
How is Lometrexol hydrate packaged and exported?
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Lometrexol hydrate is supplied as a powder and is shipped according to relevant regulations, including UN 2811 6.1 / PGIII for transport. We export globally to qualified research institutions and companies.
How can I request a quote or sample?
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To request a quote or sample of Lometrexol hydrate, please contact our sales team through the website or provide your details via the 'Request Information' form.
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