Lomustine
Lomustine (CAS: 13010-47-4, C9H16ClN3O2) is a nitrosourea alkylating agent with a molecular weight of 233.70 g/mol. It functions by cross-linking DNA, which inhibits DNA and RNA synthesis. Lomustine is primarily utilised in cancer research and cell biology studies for its DNA-modifying properties, making it a valuable tool in understanding cellular responses to genotoxic agents.
- IUPAC
- 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
- Synonyms
- 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
Antitumor Agent Research
Investigate the mechanisms of action and potential therapeutic applications of Lomustine as an alkylating agent in preclinical cancer models.
DNA Modification and Repair Studies
Utilise Lomustine to study DNA damage induction and the subsequent cellular repair pathways in various biological systems.
Cell Biology Investigations
Employ Lomustine as a research tool to probe cellular processes affected by DNA alkylation and to understand cell cycle regulation.
Cancer Research
Lomustine serves as a reference compound or investigative agent in diverse cancer research settings, particularly those focusing on chemotherapeutic strategies.
| Molecular weight | 233.70 |
|---|---|
| Empirical formula | C9H16ClN3O2 |
| Assay | ≥98% |
| Storage temperature | −20°C |
Hazard statements
- H301Toxic if swallowed
- H350May cause cancer
Precautionary statements
- P201Obtain special instructions before use
- P301IF SWALLOWED
- P308IF exposed or concerned
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 45-25 |
| Safety statements (S) | 53-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Lomustine used for?
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Lomustine is used in research for its properties as an antitumor agent, in cancer research, cell biology, and for studying DNA modification and repair.
What are the CAS number and formula for Lomustine?
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The CAS number for Lomustine is 13010-47-4 and its empirical formula is C9H16ClN3O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Lomustine with a minimum assay of ≥98%. We do not represent this product as USP, BP, or EP grade.
How should Lomustine be handled?
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Lomustine is a Danger (GHS06, GHS08) substance. Handle with appropriate personal protective equipment, including eyeshields, gloves, and a full-face particle respirator. It is harmful if swallowed and may cause cancer (H301-H350).
How is Lomustine packaged and exported?
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Lomustine is typically stored at -20°C. It is shipped and exported in compliance with relevant regulations, including UN 2811 6.1 / PGIII.
How can I request a sample or quote for Lomustine?
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To request a sample or quote for Lomustine, please contact the Tech Serve Solutions sales team via our website or listed contact information.
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