L-tert-Leucine
L-tert-Leucine (CAS 20859-02-3), also known as (S)-2-Amino-3,3-dimethylbutyric acid, is a non-proteinogenic amino acid with the molecular formula (CH3)3CCH(NH2)CO2H and a molecular weight of 131.17 g/mol. This chiral compound is valued in chemical synthesis and peptide chemistry. It is primarily used as a building block for unnatural peptides and as a chiral auxiliary in asymmetric synthesis, contributing to the development of novel pharmaceuticals and biochemicals.
- IUPAC
- (S)-2-Amino-3,3-dimethylbutyric acid,L-α-tert-Butylglycine
- Synonyms
- (S)-2-Amino-3,3-dimethylbutyric acidL-alpha-tert-Butylglycine
Peptide Synthesis
L-tert-Leucine serves as a key building block for incorporating unnatural amino acid residues into peptides. This allows for the creation of peptides with enhanced stability, modified biological activity, and novel structural properties for research and therapeutic applications.
Asymmetric Synthesis
Utilised as a chiral auxiliary or ligand, L-tert-Leucine facilitates stereoselective transformations in organic synthesis. Its bulky tert-butyl group can impart high levels of enantioselectivity, critical for the synthesis of enantiomerically pure pharmaceutical intermediates.
Chemical Biology Research
As an unnatural amino acid derivative, L-tert-Leucine is employed in chemical biology to probe protein structure and function. It can be incorporated into biomolecules to study specific interactions or to create novel protein scaffolds.
| Molecular weight | 131.17 |
|---|---|
| Linear formula | (CH3)3CCH(NH2)CO2H |
| Assay | ≥99.0% (NT) |
| Optical activity | [α]20/D +7±1°, c = 5% in 5 M HCl |
| Impurities tested | ~0.5% water |
| Melting point | ≥300 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is L-tert-Leucine used for?
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L-tert-Leucine is primarily used as a chiral building block in peptide synthesis and asymmetric organic synthesis, particularly for creating unnatural peptides and enantiomerically pure pharmaceutical intermediates.
What is the CAS number and chemical formula for L-tert-Leucine?
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The CAS number for L-tert-Leucine is 20859-02-3. Its linear formula is (CH3)3CCH(NH2)CO2H.
What grade and purity does Tech Serve Solutions supply for L-tert-Leucine?
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Tech Serve Solutions supplies L-tert-Leucine with an assay of ≥99.0% (NT), with approximately 0.5% water as an impurity. This is a technical/research grade material, and TSS does not represent it as USP, BP, EP, or any other pharmacopoeial standard.
How should L-tert-Leucine be handled safely?
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Safe handling of L-tert-Leucine requires appropriate personal protective equipment, including eyeshields and gloves. In environments where dust may be generated, a type N95 (US) or type P1 (EN143) respirator filter should be used.
Is L-tert-Leucine a controlled substance?
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The provided data does not indicate that L-tert-Leucine is a controlled substance.
How is L-tert-Leucine packed, shipped, and exported?
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L-tert-Leucine is carefully packed to ensure product integrity during transit and is available for global export by Tech Serve Solutions, a specialist supplier since 1998.
How can I request a sample or quote for L-tert-Leucine?
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To request a sample or obtain a quote for L-tert-Leucine, please contact our sales team through the designated channels on the Tech Serve Solutions website.
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