1-Fmoc-4-piperidineacetic acid
1-Fmoc-4-piperidineacetic acid (CAS: 180181-05-9; C22H23NO4) is a valuable derivative of piperidineacetic acid, widely utilised in organic synthesis and peptide chemistry. Characterised by its N-terminal Fmoc protecting group, this compound is essential for controlled solid-phase peptide synthesis (SPPS) and in the creation of complex biomolecules. With a molecular weight of 365.42 g/mol, it serves as a key building block in pharmaceutical research and development.
- IUPAC
- 1-Fmoc-piperidin-4-ylacetic acid
- Synonyms
- 1-Fmoc-piperidin-4-ylacetic acid
Peptide Synthesis
This Fmoc-protected amino acid derivative is a critical reagent in solid-phase peptide synthesis (SPPS). The Fmoc group allows for orthogonal protection strategies, facilitating the stepwise assembly of peptide chains.
Organic Synthesis
As a functionalised piperidine building block, it is employed in the synthesis of complex organic molecules. Its structure offers a versatile platform for introducing piperidine moieties into target compounds.
Chemical Biology Research
Used in research for the development of novel bioactive compounds and modified peptides. Its incorporation can influence the pharmacokinetic and pharmacodynamic properties of potential drug candidates.
Analytical Standards
Serves as a reference standard in analytical chemistry, particularly in chromatographic methods like HPLC for the identification and quantification of related substances.
| Molecular weight | 365.42 |
|---|---|
| Empirical formula | C22H23NO4 |
| Assay | ≥99.0% (HPLC) |
| Storage temperature | 2-8°C |
| Melting point | 135-138 °C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Fmoc-4-piperidineacetic acid used for?
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1-Fmoc-4-piperidineacetic acid is primarily used as a building block in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS), and in general organic synthesis for creating complex molecules.
What is the CAS number and chemical formula for 1-Fmoc-4-piperidineacetic acid?
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The CAS number is 180181-05-9, and the chemical formula is C22H23NO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-Fmoc-4-piperidineacetic acid with an assay of ≥99.0% by HPLC. This product is suitable for research and synthesis purposes. TSS does not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should 1-Fmoc-4-piperidineacetic acid be handled and stored?
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Handle with appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or P1 (EN143) respirator filter. Store at refrigerated temperatures between 2-8°C. This compound has a WGK Germany classification of 3.
Is 1-Fmoc-4-piperidineacetic acid a controlled substance?
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Based on the provided data, there is no indication that 1-Fmoc-4-piperidineacetic acid is a controlled substance.
How can I request a quote or sample for 1-Fmoc-4-piperidineacetic acid?
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Please contact our sales team via the website or by phone to request a quote or to arrange for a sample of 1-Fmoc-4-piperidineacetic acid.
How is this chemical packed and exported?
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Tech Serve Solutions packs and exports chemicals adhering to international shipping regulations for fine chemicals, ensuring safe and secure transit.
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