Indole-5-carboxaldehyde
Indole-5-carboxaldehyde (CAS: 1196-69-6), with the molecular formula C9H7NO and a molecular weight of 145.16 g/mol, is a versatile indole derivative. This compound serves as a key building block in organic synthesis. Its applications span the preparation of various biologically active molecules, including anti-proliferative and anti-inflammatory agents, protease inhibitors, and imaging probes, making it valuable in pharmaceutical research and development.
- IUPAC
- 5-Formylindole
- Synonyms
- 5-Formylindole
Preparation of Biologically Active Compounds
Indole-5-carboxaldehyde is utilised as a reactant in the synthesis of curcumin derivatives exhibiting anti-proliferative and anti-inflammatory properties. It also features in the creation of analogs for botulinum neurotoxin serotype A protease inhibitors.
Synthesis of Imaging Agents
This compound is employed in the stereoselective synthesis of dibenzylideneacetone derivatives, which are developed as β-amyloid imaging probes for research applications.
Organic Synthesis and Heterocyclic Chemistry
It acts as a reactant in processes such as the stereoselective synthesis of heteroaromatic (E)-α,β-unsaturated ketones and the preparation of para-para stilbenophanes via McMurry coupling.
Drug Design Research
Indole-5-carboxaldehyde is a precursor in structure-based drug design efforts, notably in the development of inhibitors for targets like aurora kinase A.
| Molecular weight | 145.16 |
|---|---|
| Empirical formula | C9H7NO |
| Assay | 98% |
| Application | • Reactant in preparation of curcumin derivatives as anti-proliferative & anti-inflammatory agents1• Reactant in preparation of analogs of botulinum neurotoxin serotype A protease inhibitors2• Reactant in stereoselective synthesis of dibenzylideneacetone derivatives as β-amyloid imaging probes3• Reactant in synthesis of para-para stilbenophanes by McMurry coupling4• Reactant in stereoselective synthesis of heteroaromatic (E)-α,β-unsaturated ketones from aldehydes5• Reactant in structure-based drug design of aurora kinase A inhibitors6 |
| Melting point | 100-103 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Indole-5-carboxaldehyde used for?
+
Indole-5-carboxaldehyde is used as a reactant in the synthesis of various compounds, including anti-proliferative and anti-inflammatory agents, protease inhibitor analogs, β-amyloid imaging probes, and aurora kinase A inhibitors.
What are the CAS number and formula for Indole-5-carboxaldehyde?
+
The CAS number is 1196-69-6, and the empirical formula is C9H7NO.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies Indole-5-carboxaldehyde with an assay of 98%. This product is intended for research and laboratory use; TSS does not represent it as USP, BP, or EP grade.
What are the safety and handling considerations for Indole-5-carboxaldehyde?
+
Indole-5-carboxaldehyde is classified with a Warning signal word, with hazard statements H315, H319, and H335, indicating it causes skin irritation, serious eye irritation, and may cause respiratory irritation. Appropriate personal protective equipment, including a dust mask (N95 type), eyeshields, and gloves, should be used. Handle in a well-ventilated area.
How is Indole-5-carboxaldehyde packed, shipped, and exported?
+
Indole-5-carboxaldehyde is carefully packed to ensure safe transit. Tech Serve Solutions is experienced in exporting fine chemicals globally to meet research and industrial requirements.
How can I request a sample or quote for Indole-5-carboxaldehyde?
+
To request a sample or a quote for Indole-5-carboxaldehyde, please contact the Tech Serve Solutions sales team through our website or by phone.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis