Indole-4-boronic acid pinacol ester

CAS 388116-27-6C14H18BNO2Chemical Synthesis

Indole-4-boronic acid pinacol ester (CAS: 388116-27-6) is a vital organoboron compound with the molecular formula C14H18BNO2 and a molecular weight of 243.11 g/mol. This stable boronate ester serves as a versatile building block in organic synthesis, particularly in cross-coupling reactions. Its structure facilitates the introduction of the indole moiety into complex molecules, making it valuable in pharmaceutical research and the development of novel materials.

IUPAC: 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole
Synonyms: 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole

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Indole-4-boronic acid pinacol ester (C14H18BNO2) — chemical structure, CAS 388116-27-6; Chemistry, fine chemical supplied by Tech Serve Solutions

Aryl Boronate EstersBoronate EstersChemical SynthesisOrganometallic Reagents

01 /Applications

Suzuki-Miyaura Cross-Coupling Reactions

This Indole-4-boronic acid pinacol ester is an effective coupling partner in Suzuki-Miyaura reactions. It facilitates the formation of carbon-carbon bonds, enabling the synthesis of complex biaryl and heteroaryl compounds.

Pharmaceutical Intermediate Synthesis

The compound is employed in the synthesis of pharmaceutical intermediates and active pharmaceutical ingredients (APIs). The indole scaffold is present in numerous biologically active molecules, driving demand in drug discovery.

Organic Synthesis Building Block

As a functionalised indole derivative, it acts as a key building block for constructing diverse organic molecules. Its utility spans academic research and industrial chemical development.

Materials Science Applications

The indole moiety can impart specific electronic and optical properties, making this boronate ester potentially useful in the development of organic electronic materials and functional polymers.

02 /Properties

Molecular weight	243.11
Empirical formula	C14H18BNO2
Assay	95%
Melting point	168-173 °C

03 /Safety & handling

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P305IF IN EYES

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

388116-27-6

MDL number

MFCD08689896

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Indole-4-boronic acid pinacol ester used for?

Indole-4-boronic acid pinacol ester is primarily used as a building block in organic synthesis, particularly for Suzuki-Miyaura cross-coupling reactions to create carbon-carbon bonds, and in the synthesis of pharmaceutical intermediates and novel materials.

What is the CAS number and chemical formula for Indole-4-boronic acid pinacol ester?

The CAS number is 388116-27-6 and the chemical formula is C14H18BNO2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Indole-4-boronic acid pinacol ester with a purity of 95% (assay). We do not represent this product as USP, BP, or EP grade.

What are the safety precautions for handling Indole-4-boronic acid pinacol ester?

Handle with appropriate personal protective equipment. Avoid breathing dust and ensure good ventilation. In case of contact with eyes, rinse cautiously with water for several minutes and remove contact lenses if present and easy to do. Continue rinsing.

How is Indole-4-boronic acid pinacol ester packed, shipped, and exported?

Products are carefully packed to ensure integrity during transit and are exported globally in compliance with international shipping regulations for chemical substances.