Indole-3-carboxaldehyde
Indole-3-carboxaldehyde (CAS 487-89-8), with the molecular formula C9H7NO and a molecular weight of 145.16 g/mol, is a key organic building block. This indole derivative features an aldehyde functional group, making it a versatile intermediate. It is primarily used in chemical synthesis for the preparation of more complex indole-based compounds and heterocyclic structures, serving as a valuable reagent in research and development laboratories.
- IUPAC
- β-Indolylaldehyde,3-Indolylformaldehyde,3-Formylindole,Indole-3-carbaldehyde,NSC 10118
- Synonyms
- β-Indolylaldehyde3-Indolylformaldehyde3-FormylindoleIndole-3-carbaldehydeNSC 10118
Synthesis of Indole Analogs
Indole-3-carboxaldehyde serves as a precursor for synthesising various indole analogs, including those with modified phytoalexin structures. These compounds are often explored for their biological activities.
Preparation of Complex Heterocycles
It is employed in the synthesis of higher-order indoles and fused heterocyclic systems, such as isoindolo[2,1-a]indoles and tetrahydrobenz[cd]indoles, expanding the scope of organic synthesis.
Aplysinopsin Synthesis
This aldehyde is a starting material in the synthetic routes towards aplysinopsins, a class of marine natural products known for their unique chemical structures.
| Molecular weight | 145.16 |
|---|---|
| Empirical formula | C9H7NO |
| Assay | ≥98.0% (T) |
| Application | Indole-3-carboxaldehyde was used to prepare analogs of the indole phytoalexin cyclobrassinin with NR1R2 group1. It was also used as the starting material for the synthesis of higher order indoles including isoindolo[2,1-a]indoles,2 aplysinopsins,3 and 4-substituted-tetrahydrobenz[cd]indoles.4 |
| Melting point | 193-198 °C(lit.)193-198 °C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Indole-3-carboxaldehyde used for?
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Indole-3-carboxaldehyde is used in chemical synthesis as a building block for preparing various indole derivatives, complex heterocycles, and analogs of natural products. Its aldehyde functional group allows for diverse chemical transformations.
What are the CAS number and formula for Indole-3-carboxaldehyde?
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The CAS number for Indole-3-carboxaldehyde is 487-89-8, and its empirical formula is C9H7NO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Indole-3-carboxaldehyde with an assay of ≥98.0% (T). This is a technical/research grade material, and TSS does not represent it as USP, BP, EP, or any other pharmacopoeial standard.
How should Indole-3-carboxaldehyde be handled safely?
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Indole-3-carboxaldehyde requires careful handling. Recommended personal protective equipment includes eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is advised. Refer to the Safety Data Sheet for comprehensive handling information.
Is Indole-3-carboxaldehyde a controlled substance?
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The provided data does not indicate that Indole-3-carboxaldehyde (CAS 487-89-8) is a controlled substance.
How is Indole-3-carboxaldehyde packed, shipped, and exported?
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Indole-3-carboxaldehyde is carefully packed to ensure its integrity during transit. Tech Serve Solutions is a specialist global supplier and exporter, handling all necessary documentation for international shipments.
How can I request a sample or quote for Indole-3-carboxaldehyde?
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To request a sample or quote for Indole-3-carboxaldehyde, please contact our sales team through the website or by phone, providing your specific requirements.
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