Indole-4-carboxaldehyde
Indole-4-carboxaldehyde (CAS: 1074-86-8), with the molecular formula C9H7NO and a molecular weight of 145.16 g/mol, is a valuable heterocyclic building block. This indole derivative serves as a key intermediate in organic synthesis, particularly in the preparation of pharmaceutical agents and complex organic molecules. Its aldehyde functionality allows for diverse chemical transformations, making it a sought-after reagent for researchers and chemical manufacturers.
- IUPAC
- 4-Formylindole,NSC 337264
Synthesis of Aurora Kinase A Inhibitors
Indole-4-carboxaldehyde is utilised as a reactant in the synthesis of compounds designed to inhibit Aurora kinase A, a target in cancer research.
Preparation of Antitumor Agents
This compound serves as a precursor in the development of novel antitumor agents, highlighting its importance in medicinal chemistry.
Reactant in Biginelli Reaction
Indole-4-carboxaldehyde participates in the Biginelli reaction, a multi-component reaction useful for creating dihydropyrimidines and related structures.
Intramolecular Friedel-Crafts Acylation
It is employed as a reactant in intramolecular Friedel-Crafts acylation reactions, a fundamental method for ring formation in organic synthesis.
| Molecular weight | 145.16 |
|---|---|
| Empirical formula | C9H7NO |
| Assay | 97% |
| Application | • reactant in Biginelli reaction1• reactant in synthesis of aurora kinase A inhibitors2• reactant in preparation of antitumor agents3• reactant in intramolecular Friedel-Crafts acylation4• reactant in preparation of inhibitors of cell division in E. coli5• reactant in synthesis of Hantzsch pyridine-containing Schiff bases6 |
| Melting point | 139-143 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H317May cause an allergic skin reaction
- H319Causes serious eye irritation
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36-43 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Indole-4-carboxaldehyde used for?
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Indole-4-carboxaldehyde is used as a reactant in various synthetic organic chemistry applications, including the Biginelli reaction, the synthesis of aurora kinase A inhibitors, the preparation of antitumor agents, and intramolecular Friedel-Crafts acylation.
What are the CAS number and formula for Indole-4-carboxaldehyde?
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The CAS number for Indole-4-carboxaldehyde is 1074-86-8, and its molecular formula is C9H7NO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Indole-4-carboxaldehyde with an assay of 97%. We do not represent this product as USP, BP, or EP grade.
How should Indole-4-carboxaldehyde be handled safely?
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Indole-4-carboxaldehyde is classified as a Warning substance with hazard statements H302 (Harmful if swallowed), H317 (May cause an allergic skin reaction), and H319 (Causes serious eye irritation). Appropriate personal protective equipment, including a dust mask type N95, eyeshields, faceshields, and gloves, should be worn during handling. Consult the Safety Data Sheet for comprehensive safety information.
Is Indole-4-carboxaldehyde a controlled substance?
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The provided data does not indicate that Indole-4-carboxaldehyde is a controlled substance.
How is Indole-4-carboxaldehyde packed, shipped, and exported?
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Information regarding specific packing, shipping, and export details can be obtained by contacting our sales team.
How can I request a sample or quote for Indole-4-carboxaldehyde?
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To request a sample or a quote for Indole-4-carboxaldehyde, please contact our customer service department via the website or by phone.
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