Indole-6-carboxylic acid
Indole-6-carboxylic acid (CAS: 1670-82-2), a valuable organic compound with the molecular formula C9H7NO2 and a molecular weight of 161.16 g/mol, serves as a key building block in chemical synthesis. Its indole structure makes it particularly useful in the preparation of various biologically active molecules and pharmaceutical intermediates. This compound is supplied by TSS for research and development purposes.
- IUPAC
- 6-Carboxyindole
Preparation of E. coli MurD Ligase Inhibitors
Indole-6-carboxylic acid is utilized as a reactant in the synthesis of D-glutamic acid-based inhibitors designed to target E. coli MurD ligase, an enzyme essential for bacterial cell wall biosynthesis.
Synthesis of Kinase Inhibitors
It serves as a precursor for creating indolylindazoles and indolylpyrazolopyridines, compounds investigated for their potential as inhibitors of interleukin-2 inducible T cell kinase (ITK).
Development of Hedgehog Pathway Modulators
This compound is employed in the preparation of amide conjugates with ketoprofen, which are studied for their inhibitory effects on Gli1-mediated transcription within the Hedgehog signalling pathway.
Antagonists for Human Growth Hormone Secretagogue Receptor
Indole-6-carboxylic acid is a reactant in the synthesis of piperazine-bisamide analogues, investigated as potential antagonists for the human growth hormone secretagogue receptor for obesity treatment.
SARS-CoV 3CL Protease Inhibitors
The compound is used in esterification reactions with chlorohydroxypyridine to prepare pyridinyl carboxylates, which are being explored as inhibitors of the SARS-CoV 3CL protease.
| Molecular weight | 161.16 |
|---|---|
| Empirical formula | C9H7NO2 |
| Assay | ≥97.0% (T) |
| Application | • Reactant for preparation of D-glutamic acid-based inhibitors of E. coli MurD ligase1• Reactant for preparation of indolylindazoles and indolylpyrazolopyridines as interleukin-2 inducible T cell kinase inhibitors2• Reactant for preparation of amide conjugates with ketoprofen, as inhibitors of Gli1-mediated transcription in Hedgehog pathway3• Reactant for preparation of piperazine-bisamide analogs as human growth hormone secretagogue receptor antagonists for treatment of obesity4• Reactant for preparation of pyridinyl carboxylates via esterification with chlorohydroxypyridine as SARS-CoV 3CL proinhibitors5• Reactant for preparation of (indolecarbonyl)-D-phenylglycinamide amides as factor Xa inhibitors6 |
| Melting point | 249-253 °C(lit.)~255 °C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Indole-6-carboxylic acid used for?
+
Indole-6-carboxylic acid is primarily used as a reactant and building block in chemical synthesis, particularly for the preparation of various pharmaceutical intermediates and biologically active compounds, including kinase inhibitors and enzyme inhibitors.
What are the CAS number and formula for Indole-6-carboxylic acid?
+
The CAS number for Indole-6-carboxylic acid is 1670-82-2, and its molecular formula is C9H7NO2.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies Indole-6-carboxylic acid with a purity of ≥97.0% (T). TSS does not represent this product as USP, BP, or EP grade.
How should Indole-6-carboxylic acid be handled?
+
When handling Indole-6-carboxylic acid, it is recommended to use safety measures such as eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used if respiratory protection is needed. The compound has a German Water Hazard Class (WGK) of 3.
Is Indole-6-carboxylic acid a controlled substance?
+
Based on the provided data, there is no indication that Indole-6-carboxylic acid is a controlled substance.
How is Indole-6-carboxylic acid packed, shipped, and exported?
+
Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and can provide Indole-6-carboxylic acid internationally. Specific packing and shipping details can be provided upon request.
How can I request a quote or sample of Indole-6-carboxylic acid?
+
To request a quote or a sample of Indole-6-carboxylic acid, please contact the Tech Serve Solutions sales team through the official website or designated contact channels.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis