Indoline
Indoline (CAS 496-15-1), with the molecular formula C8H9N and a molecular weight of 119.16 g/mol, is a key heterocyclic building block. It serves as a crucial intermediate in the synthesis of a diverse range of biologically active compounds. Its structure facilitates its use in developing novel pharmaceuticals, including inhibitors for various signalling pathways and receptor antagonists, underscoring its importance in medicinal chemistry research and development.
- IUPAC
- 1-Azaindan,2,3-Dihydroindole
- Synonyms
- 2,3-Dihydroindole1-Azaindan
Pharmaceutical Intermediate
Indoline is a versatile reactant used in the synthesis of compounds with potential therapeutic applications. This includes the development of inhibitors for NOD1-induced nuclear factor-κB activation and sphingosine-1-phosphate receptor antagonists.
Synthesis of Bioactive Molecules
This compound is instrumental in preparing cytotoxic cell cycle inhibitors and selective partial agonists for α4β2-nicotinic acetylcholine receptors. It is also employed in creating PET agents for imaging protein kinase C (PKC).
Drug Discovery Reagent
Indoline is utilised in the discovery of new drug candidates, such as sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for diabetes management and bacterial biofilm inhibitors.
Neuroscience Research
It serves as a building block for compounds targeting the central nervous system, including mGlu4 positive allosteric modulators and serotonin 5-HT6 receptor antagonists.
| Molecular weight | 119.16 |
|---|---|
| Empirical formula | C8H9N |
| Assay | ≥98.0% (GC) |
| Boiling point | 220-221 °C(lit.) |
| Density | 1.063 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.592(lit.)n20/D 1.592 |
| Application | Reactant for preparation of:• Inhibitors of NOD1-Induced Nuclear Factor-κB Activation1• Sphingosine-1-phosphate 4(S1P4) receptor antagonists2• Cytotoxic cell cycle inhibitors3• 2-Aminopyridines4• PET agent for imaging of protein kinase C (PKC)5• Sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes6• α4β2-Nicotinic acetylcholine receptor-selective partial agonists7• mGlu4 positive allosteric modulators8• Bacterial biofilm inhibitors9• Serotonin 5-HT6 receptor antagonists10 |
| Flash point | 93 °C / 199.4 °F |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Indoline used for?
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Indoline is primarily used as a reactant for the preparation of various pharmaceutical intermediates and biologically active compounds, including inhibitors, receptor antagonists, and agents for medical imaging.
What are the CAS number and formula for Indoline?
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The CAS number for Indoline is 496-15-1, and its empirical formula is C8H9N.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Indoline with an assay of ≥98.0% (GC). This product is not supplied as USP, BP, EP, or any other pharmacopoeia grade and TSS does not represent it as such.
What are the safety hazards associated with Indoline?
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Indoline is a combustible liquid with a flash point of 93 °C (199.4 °F). It is classified under WGK Germany 3, indicating a high hazard to water. Appropriate safety precautions must be taken during handling and storage.
How is Indoline packed, shipped, and exported?
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Indoline is carefully packed to ensure safe transit and is available for export globally by Tech Serve Solutions, adhering to all relevant shipping regulations.
How can I request a sample or quote for Indoline?
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To request a sample or a quotation for Indoline, please contact our sales team through the website or by direct inquiry.
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