6-Anilinoquinoline-5,8-quinone
6-Anilinoquinoline-5,8-quinone (CAS 91300-60-6) is a violet solid compound with a molecular weight of 250.25. This molecule acts as an inhibitor of soluble guanylate cyclase and cyclic guanosine monophosphate (cGMP) production. It also demonstrates the ability to block intracellular calcium (Ca <sup>2+</sup> ) release and antigen-induced leukotriene synthesis. Primarily utilised in biological research, it serves as a valuable tool for investigating cellular signalling pathways and related physiological processes.
- IUPAC
- 6-(Phenylamino)-5,8-quinolinedione,LY-83,583,LY83583
- Synonyms
- C15H10N2O26-(Phenylamino)-5,8-quinolinedioneLY-83,583LY83583
Soluble Guanylate Cyclase Inhibition
This compound effectively inhibits soluble guanylate cyclase (sGC), a key enzyme in the nitric oxide (NO) signalling pathway. By blocking sGC, it reduces the production of cyclic guanosine monophosphate (cGMP), providing a tool for research into NO-mediated physiological effects.
Calcium and Leukotriene Pathway Research
6-Anilinoquinoline-5,8-quinone interferes with intracellular calcium release and inhibits the synthesis of leukotrienes induced by antigens. This dual action makes it useful for studying inflammatory responses and related cellular mechanisms.
Cellular Signalling Studies
As a bioactive small molecule, it is employed in cell biology and neuroscience research to probe complex cellular signalling cascades. Its specific inhibitory actions aid in understanding the roles of cGMP and calcium in various cellular functions.
| Molecular weight | 250.25 |
|---|---|
| Empirical formula | C15H10N2O2 |
| Assay | ≥95% (TLC) |
| Form | solid |
| Colour | violet |
| Solubility | 0.1 M HCl: soluble1 mg/mLmethanol: soluble11 mg/mLethanol: soluble8 mg/mL |
| Storage temperature | 2-8°C |
| Application | 6-Anilinoquinoline-5,8-quinone inhibits soluble guanylate cyclase and cGMP production. 6-Anilinoquinoline-5,8-quinone also blocks the release of intracellular Ca2+ and antigen-induced leukotrienes. |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 6-Anilinoquinoline-5,8-quinone used for?
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6-Anilinoquinoline-5,8-quinone is used in biological research to inhibit soluble guanylate cyclase and cGMP production. It also blocks intracellular Ca <sup>2+</sup> release and antigen-induced leukotrienes, making it valuable for studying cellular signalling, inflammation, and neuroscience.
What are the CAS number and formula for 6-Anilinoquinoline-5,8-quinone?
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The CAS number for 6-Anilinoquinoline-5,8-quinone is 91300-60-6. Its empirical formula is C15H10N2O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 6-Anilinoquinoline-5,8-quinone with a minimum purity of ≥95% (TLC). This product is intended for research and laboratory use; it is not supplied as USP, BP, EP, or pharmacopoeia grade.
How should 6-Anilinoquinoline-5,8-quinone be handled safely?
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6-Anilinoquinoline-5,8-quinone is classified as a warning substance, causing skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, ensuring good ventilation. Avoid breathing dust and contact with skin and eyes. Store in a cool, dry place, preferably under refrigeration (2-8°C).
How is this chemical packed, shipped, and exported?
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Tech Serve Solutions securely packs and exports 6-Anilinoquinoline-5,8-quinone globally. Packaging complies with international shipping regulations for chemical products to ensure safe transit and integrity upon arrival.
How can I request a sample or quote for 6-Anilinoquinoline-5,8-quinone?
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To request a sample or a formal quotation for 6-Anilinoquinoline-5,8-quinone, please contact our sales department through the website or by direct inquiry, providing your contact details and the required quantity.
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