ICI 216,140

CAS 124001-41-8C45H65N13O8Biochemicals & Reagents

ICI 216,140 (CAS: 124001-41-8) is a synthetic peptide with the molecular formula C45H65N13O8 and a molecular weight of 916.08. This white solid compound functions as a bombesin receptor antagonist, playing a role in cell signalling research. It is specifically indicated for studies in cell biology, neuroscience, and GPCR modulation, offering a valuable tool for investigating G protein-coupled receptor pathways.

IUPAC: (CH3)2CHCO-His-Trp-Ala-Val-D-Ala-His-Leu-NHCH3
Synonyms: C45H65N13O8

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ICI 216,140 (C45H65N13O8) — chemical structure, CAS 124001-41-8; Life Science, fine chemical supplied by Tech Serve Solutions

Biochemicals and ReagentsCell BiologyGPCR ModulatorsGPCR ProteinsModulators and AntibodiesOther PeptidesPeptides and ProteinsPeptides for Cell Biology

01 /Applications

Bombesin Receptor Antagonism Research

ICI 216,140 acts as a potent antagonist for bombesin receptors, making it useful for studying the physiological roles and signalling pathways mediated by these receptors in various biological systems.

Cell Biology and Signaling Studies

As a tool in cell biology, this peptide aids in investigating cellular responses and intracellular signalling cascades involving G protein-coupled receptors (GPCRs).

Neuroscience Research Applications

Its ability to modulate GPCRs makes ICI 216,140 valuable for neuroscience research, particularly in understanding receptor function within the central nervous system.

02 /Properties

Molecular weight	916.08
Empirical formula	C45H65N13O8
Assay	>95%
Form	solid
Colour	white
Storage temperature	−20°C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

124001-41-8

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is ICI 216,140 primarily used for?

ICI 216,140 is primarily used as a bombesin receptor antagonist in research settings, particularly for studies in cell biology, cell signaling, neuroscience, and GPCR modulation.

What are the CAS number and molecular formula for ICI 216,140?

The CAS number for ICI 216,140 is 124001-41-8, and its empirical formula (Hill notation) is C45H65N13O8.

What grade and purity does Tech Serve Solutions supply for ICI 216,140?

Tech Serve Solutions supplies ICI 216,140 with an assay of >95%. We do not represent this product as meeting USP, BP, or EP pharmacopoeia standards.

What are the safety and handling precautions for ICI 216,140?

Handling ICI 216,140 requires appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. It is classified under WGK Germany 3, indicating a high hazard to water.

How is ICI 216,140 typically supplied and shipped?

ICI 216,140 is supplied as a white solid and stored at -20°C. TSS is a global supplier and exporter, providing appropriate packaging for safe international shipment.