ICI 63,197

CAS 27277-00-5C9H13N5OBiochemicals & Reagents

ICI 63,197 (CAS: 27277-00-5), a bioactive small molecule with the empirical formula C9H13N5O, is a chemical compound with a molecular weight of 207.23 g/mol. This white powder is primarily recognised for its role as a selective phosphodiesterase IV (PDE4) inhibitor. Its specific action makes it a valuable tool in biochemical research, particularly in studies investigating cellular signalling pathways and inflammatory responses.

IUPAC: 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one
Synonyms: 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one

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ICI 63,197 (C9H13N5O) — chemical structure, CAS 27277-00-5; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesBiochemicals and ReagentsCell BiologyEnzyme InhibitorsEnzyme Inhibitors by EnzymeEnzymesInhibitorsand SubstratesP to QPhosphodiesterase IV More...

01 /Applications

Phosphodiesterase IV Inhibition

ICI 63,197 acts as a potent and selective inhibitor of phosphodiesterase IV (PDE4). This enzyme plays a crucial role in regulating intracellular levels of cyclic adenosine monophosphate (cAMP), a key second messenger in various cellular processes. Research utilising ICI 63,197 can explore the downstream effects of PDE4 inhibition.

Cellular Signalling Research

As a modulator of cAMP levels, ICI 63,197 is instrumental in studying cellular signalling pathways. It enables researchers to investigate how changes in cAMP concentration influence cell function, proliferation, and differentiation. This makes it a useful reagent in cell biology laboratories.

Inflammatory Response Studies

Phosphodiesterase IV is implicated in inflammatory processes. ICI 63,197 can be employed in preclinical research to investigate the role of PDE4 in modulating inflammatory responses, potentially offering insights into therapeutic targets for inflammatory diseases.

02 /Properties

Molecular weight	207.23
Empirical formula	C9H13N5O
Assay	≥98% (HPLC)
Form	powder
Colour	white
Solubility	DMSO: soluble13 mg/mL
Storage temperature	2-8°C
Melting point	161.8-163 °C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	1

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

27277-00-5

MDL number

MFCD06407961

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is ICI 63,197 used for?

ICI 63,197 is primarily used in research as a selective phosphodiesterase IV (PDE4) inhibitor to study cellular signalling pathways and inflammatory responses.

What are the CAS number and formula for ICI 63,197?

The CAS number for ICI 63,197 is 27277-00-5 and its empirical formula is C9H13N5O.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies ICI 63,197 with a purity of ≥98% (HPLC). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.

What are the safety and handling recommendations for ICI 63,197?

When handling ICI 63,197, it is essential to use personal protective equipment including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is also recommended. Store the compound at 2-8°C.

How is ICI 63,197 shipped and exported?

Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including ICI 63,197, and adheres to all relevant regulations for international shipment.