Fmoc-β-Phe-OH
Fmoc-β-Phe-OH (CAS 220498-02-2), with the molecular formula C24H21NO4 and a molecular weight of 387.43 g/mol, is a valuable unnatural amino acid derivative. Utilised in peptide chemistry and chemical synthesis, it serves as a crucial building block for creating novel peptides and complex organic molecules. Its unique beta-amino acid structure offers distinct conformational properties compared to standard alpha-amino acids, enabling the design of peptides with enhanced stability or altered biological activity.
- IUPAC
- (R)-3-(Fmoc-amino)-3-phenylpropionic acid,Fmoc-L-β-phenylalanine

Peptide Synthesis
Fmoc-β-Phe-OH is employed as a key building block in solid-phase and solution-phase peptide synthesis. Its incorporation allows for the creation of peptidomimetics and peptides with modified backbones, potentially leading to improved pharmacokinetic profiles or novel therapeutic applications.
Chemical Biology Research
This unnatural amino acid derivative is used in chemical biology to probe protein structure-function relationships or to develop peptide-based probes. Its unique structural features can be leveraged to study biological processes with greater specificity.
Organic Synthesis
As a versatile chiral intermediate, Fmoc-β-Phe-OH finds application in the synthesis of complex organic molecules. Its protected amino group and carboxylic acid functionality allow for diverse derivatization strategies in multi-step synthetic routes.
| Molecular weight | 387.43 |
|---|---|
| Empirical formula | C24H21NO4 |
| Assay | ≥98.0% |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-β-Phe-OH used for?
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Fmoc-β-Phe-OH is primarily used in peptide synthesis and chemical biology research as a building block for unnatural amino acids, enabling the creation of novel peptides and peptidomimetics with unique structural and functional properties.
What is the CAS number and chemical formula for Fmoc-β-Phe-OH?
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The CAS number for Fmoc-β-Phe-OH is 220498-02-2, and its empirical formula is C24H21NO4.
What grade and purity does Tech Serve Solutions supply for Fmoc-β-Phe-OH?
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Tech Serve Solutions supplies Fmoc-β-Phe-OH with an assay of ≥98.0%. We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should Fmoc-β-Phe-OH be handled and stored?
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Fmoc-β-Phe-OH requires careful handling using appropriate personal protective equipment, including eyeshields and gloves. It should be stored at 2-8°C. Refer to the safety data sheet for comprehensive handling instructions.
Is Fmoc-β-Phe-OH a controlled substance?
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The provided data does not indicate that Fmoc-β-Phe-OH is a controlled substance.
How is Fmoc-β-Phe-OH packed and shipped?
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Fmoc-β-Phe-OH is carefully packed to ensure stability during transit and is exported globally by Tech Serve Solutions in compliance with all relevant regulations.
How can I request a sample or quote for Fmoc-β-Phe-OH?
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To request a sample or a quote for Fmoc-β-Phe-OH, please contact our sales team through the website or by phone, providing your specific requirements.
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