Fmoc-β-azido-Ala-OH
Fmoc-β-azido-Ala-OH (CAS: 684270-46-0, Formula: C18H16N4O4, MW: 352.34) is a protected amino acid derivative featuring an azide group. This compound serves as a valuable building block in organic synthesis, particularly for peptide chemistry and bioconjugation. Its structure allows for post-translational modification and the introduction of non-canonical amino acids into peptide chains via click chemistry.
- IUPAC
- (S)-3-Azido-2-(Fmoc-amino)propionic acid,Fmoc-3-azido-L-alanine
- Synonyms
- (S)-3-Azido-2-(Fmoc-amino)propionic acidFmoc-3-azido-L-alanine
Peptide Synthesis
Fmoc-β-azido-Ala-OH is used in solid-phase peptide synthesis (SPPS) to incorporate azido-alanine residues. This enables subsequent chemical modifications, such as strain-promoted alkyne-azide cycloaddition (SPAAC) or copper-catalyzed azide-alkyne cycloaddition (CuAAC), to create modified peptides.
Bioconjugation
The azide functionality makes this compound ideal for bioconjugation strategies. It can be used to link peptides to other biomolecules or surfaces, facilitating the development of novel diagnostic tools, targeted drug delivery systems, and research reagents.
Chemical Biology
Researchers in chemical biology utilise Fmoc-β-azido-Ala-OH to study protein function and develop molecular probes. The introduction of azido groups allows for metabolic labelling and subsequent imaging or pull-down experiments.
Organic Synthesis Building Block
Beyond peptide chemistry, this compound is a versatile synthon for constructing complex organic molecules. The orthogonal reactivity of the azide and Fmoc-protected amine groups offers flexibility in synthetic design.
| Molecular weight | 352.34 |
|---|---|
| Empirical formula | C18H16N4O4 |
| Assay | ≥98.0% (HPLC) |
| Optical activity | [α]/D -10.0±1.0°, c = 1 in DMF |
| Storage temperature | 2-8°C |
| Impurities tested | 15.3-16.5% nitrogen60.1-62.5% carbon |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-β-azido-Ala-OH used for?
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Fmoc-β-azido-Ala-OH is primarily used as a building block in peptide synthesis, bioconjugation, and chemical biology research. Its azido group allows for click chemistry reactions, enabling the creation of modified peptides and the labelling of biomolecules.
What are the CAS number and formula for Fmoc-β-azido-Ala-OH?
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The CAS number is 684270-46-0, and the empirical formula is C18H16N4O4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-β-azido-Ala-OH with a purity of ≥98.0% (HPLC). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety and handling precautions for Fmoc-β-azido-Ala-OH?
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This compound is classified with the GHS07 symbol and a 'Warning' signal word. It carries hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be used. Handle in a well-ventilated area.
Is Fmoc-β-azido-Ala-OH available for international export?
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Yes, Tech Serve Solutions specialises in the global supply and export of fine chemicals, including Fmoc-β-azido-Ala-OH.
How can I request a quote or sample?
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Please contact our sales team directly through our website or by phone to request a quote or a sample of Fmoc-β-azido-Ala-OH.
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