1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole
1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole (CAS: 16502-01-5) is a heterocyclic organic compound with the molecular formula C11H12N2 and a molecular weight of 172.23 g/mol. This indole derivative serves as a crucial building block in organic synthesis. Its applications span the preparation of various biologically active molecules, including potential pharmaceutical intermediates and research compounds.
- IUPAC
- Noreleagnine,THBC,Tetrahydronorharman,Tryptoline
- Synonyms
- 4-Tetrahydro-9H-pyrido[3,4-b]indoleTryptolineTetrahydronorharmanNoreleagnine
![1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole (C11H12N2) — chemical structure, CAS 16502-01-5; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F16502-01-5.png&w=3840&q=75)
Synthesis of Bioactive Molecules
Utilised as a reactant in the synthesis of novel compounds, including potential inhibitors for enzymes like HDAC6, CDK4, and Aurora A kinase, as well as EGFR. It is also employed in the preparation of human 5-HT5A receptor ligands.
Preparation of Dihydrofolate Reductase Inhibitors
Serves as a precursor for the synthesis of 5-(diaminomethyl)-2,4-diaminopyrimidines, which are investigated for their potential as dihydrofolate reductase inhibitors and antibacterial agents.
Intermediate for Indolyl-β-Carboline Alkaloids
Functions as a reactant in the oxidative aromatization to form indolyl-β-carboline alkaloids, such as eudistomin U.
Research and Development
A valuable building block for chemists in academic and industrial research settings exploring new chemical entities and synthetic pathways.
| Molecular weight | 172.23 |
|---|---|
| Empirical formula | C11H12N2 |
| Assay | 98% |
| Application | • Reactant for synthesis of the indolyl-β-carboline alkaloid eudistomin U via IBX mediated room temperature oxidative aromatization• Reactant for preparation of neuroprotective HDAC6 inhibitors• Reactant for preparation of aminofuranopyrimidines as EGFR and Aurora A kinase inhibitors• Reactant for preparation of inhibitors of CDK4• Reactant for preparation of tetrahydrocarboline derivatives of as human 5-HT5A receptor ligands• Reactant for preparation of 5-(diaminomethyl)-2,4-aminopyrimidines as dihydrofolate reductase inhibitors and antibacterial agents |
| Melting point | 206-208 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | rat ... Htr2a(29595), Htr2c(25187) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole used for?
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1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole is used as a reactant and building block in organic synthesis, particularly for preparing various biologically active compounds such as enzyme inhibitors, receptor ligands, and alkaloids.
What are the CAS number and molecular formula?
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The CAS number is 16502-01-5, and the molecular formula is C11H12N2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound at an assay of 98%. It is intended for research and laboratory use and is not represented as USP, BP, EP, or any other pharmacopoeial grade.
What are the primary safety concerns when handling this chemical?
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This compound is a Warning substance and may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be used. Handle in a well-ventilated area.
How is 1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole packed, shipped, and exported?
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Tech Serve Solutions packs, ships, and exports fine chemicals and laboratory reagents globally, adhering to all relevant regulations for safe transport.
How can I request a sample or quote?
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To request a sample or a quote, please contact the Tech Serve Solutions sales team through our website or by calling our office.
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