Ethyl nitroacetate
Ethyl nitroacetate (CAS: 626-35-7; Formula: NO2CH2CO2C2H5) is a versatile organic compound with a molecular weight of 133.10 g/mol. Utilized as a valuable building block in organic synthesis, it features a nitro group and an ester functionality. Its applications span the creation of complex molecules, including nucleoside derivatives and amino acids, making it a key reagent for researchers and industrial chemists.
Synthesis of γ-Oxoacids
Ethyl nitroacetate serves as a crucial reagent in the Michael addition reaction with α,β-unsaturated ketones, facilitating the synthesis of γ-oxoacids.
Nucleoside Functionalization
It is employed in the functionalization of pyrimidine and 2′-deoxyguanosine, enabling the production of novel nucleoside analogues for research purposes.
Amino Acid Synthesis
This compound is instrumental in the facile synthesis of specific amino acids, such as α,α-diisobutylglycine.
Fluorinated Compound Synthesis
Ethyl nitroacetate is utilized in the preparation of fluorinated compounds, including DL-4,4-difluoroglutamic acid.
| Molecular weight | 133.10 |
|---|---|
| Linear formula | NO2CH2CO2C2H5 |
| Assay | ≥96.0% (GC) |
| Boiling point | 105-107 °C/25 mmHg(lit.) |
| Density | 1.199 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.424(lit.)n20/D 1.424 |
| Application | Ethyl nitroacetate has been used in:• synthesis of γ-oxoacids via Michael addition reaction with α,β-unsaturated ketones1• fuctionalization of C4-position on pyrimidine and C6-position on 2′-deoxyguanosine to produce novel nucleosides2 • facile synthesis of α,α-diisobutylglycine3• synthesis of DL-4,4-difluoroglutamic acid4 |
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 92 °C / 197.6 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 2 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl Nitroacetate used for?
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Ethyl nitroacetate is used as a building block in organic synthesis for applications including the preparation of γ-oxoacids, functionalized nucleosides, and specific amino acids.
What are the CAS number and formula for Ethyl Nitroacetate?
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The CAS number for Ethyl Nitroacetate is 626-35-7, and its chemical formula is NO2CH2CO2C2H5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ethyl Nitroacetate with a purity of ≥96.0% (GC). We do not represent this product as USP, BP, or EP grade.
What are the safety considerations when handling Ethyl Nitroacetate?
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Ethyl Nitroacetate is a combustible liquid. Handling requires appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, and should be performed in a well-ventilated area away from ignition sources.
How is Ethyl Nitroacetate packed, shipped, and exported?
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Ethyl Nitroacetate is carefully packed according to international shipping regulations and is exported globally by Tech Serve Solutions to meet your research and development needs.
How can I request a sample or quote for Ethyl Nitroacetate?
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To request a sample or a quotation for Ethyl Nitroacetate, please contact our sales team through the website or by calling us directly. We will be pleased to assist you.
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