Fmoc-Nva-OH
Fmoc-Nva-OH (CAS: 135112-28-6), with the molecular formula C20H21NO4 and a molecular weight of 339.39 g/mol, is a valuable derivative of the unnatural amino acid norvaline. This compound is primarily utilised in peptide synthesis and chemical biology research. Its N-terminal Fmoc protecting group allows for controlled solid-phase peptide synthesis, making it a key reagent in the construction of complex peptides and peptidomimetics.
- IUPAC
- Fmoc-L-norvaline
Peptide Synthesis
Fmoc-Nva-OH is employed in solid-phase peptide synthesis (SPPS) using Fmoc chemistry. It enables the incorporation of the non-proteinogenic amino acid norvaline into peptide sequences for modified biological activity or structural studies.
Chemical Biology Research
As an unnatural amino acid derivative, Fmoc-Nva-OH is used in the design and synthesis of novel peptides for investigating biological pathways, protein function, and developing new therapeutic agents.
Drug Discovery and Development
This compound serves as a building block in medicinal chemistry for the synthesis of peptidomimetics and modified peptides, potentially leading to new drug candidates with enhanced stability or efficacy.
| Molecular weight | 339.39 |
|---|---|
| Empirical formula | C20H21NO4 |
| Assay | ≥98.0% (HPLC) |
| Optical activity | [α]20/D −21±1°, c = 2% in DMF |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Nva-OH used for?
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Fmoc-Nva-OH is primarily used in solid-phase peptide synthesis and chemical biology research as a building block for incorporating norvaline into peptides and creating peptidomimetics.
What is the CAS number and molecular formula for Fmoc-Nva-OH?
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The CAS number is 135112-28-6 and the molecular formula is C20H21NO4.
What grade and purity does Tech Serve Solutions supply for Fmoc-Nva-OH?
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Tech Serve Solutions supplies Fmoc-Nva-OH with an assay of ≥98.0% (HPLC). This product is intended for research purposes and is not represented as USP, BP, EP, or pharmaceutical grade.
How should Fmoc-Nva-OH be handled and stored?
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Handle Fmoc-Nva-OH with appropriate personal protective equipment, including eyeshields and gloves. A respirator filter (type N95 or P1) may be necessary. Store the compound at 2-8°C.
Is Fmoc-Nva-OH a hazardous substance?
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Yes, Fmoc-Nva-OH is classified with a WGK (Germany) of 3, indicating a high hazard level. Appropriate safety precautions must be taken during handling and storage.
How can I request a sample or quote for Fmoc-Nva-OH?
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Please contact our sales team via the website or direct email to request a sample or a quotation for Fmoc-Nva-OH.
Does Tech Serve Solutions export Fmoc-Nva-OH?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including Fmoc-Nva-OH.
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