Fmoc-Nle-OH
Fmoc-Nle-OH (CAS: 77284-32-3) is a valuable derivative of norleucine, featuring the Fmoc (9-fluorenylmethoxycarbonyl) protecting group. With the chemical formula C21H23NO4 and a molecular weight of 353.41 g/mol, it is primarily utilised in peptide synthesis and chemical biology research. This compound serves as a building block for creating complex peptides and modified amino acid structures, contributing to advancements in biochemical studies and drug discovery.
- IUPAC
- (S)-2-(Fmoc-amino)caproic acid,(S)-2-(Fmoc-amino)hexanoic acid,N-(9-Fluorenylmethoxycarbonyl)-L-norleucine,Fmoc-L-norleucine
- Synonyms
- N-(9-Fluorenylmethoxycarbonyl)-L-norleucine(S)-2-(Fmoc-amino)caproic acid(S)-2-(Fmoc-amino)hexanoic acidFmoc-L-norleucine
Peptide Synthesis
Fmoc-Nle-OH is a key component in solid-phase and solution-phase peptide synthesis. The Fmoc group allows for controlled deprotection and chain elongation, facilitating the construction of custom peptide sequences for research and therapeutic development.
Chemical Biology
As an unnatural amino acid derivative, it enables the incorporation of non-proteinogenic amino acids into peptides. This is crucial for studying protein structure-function relationships, developing enzyme inhibitors, and creating novel biomaterials.
Biochemical Research
Researchers utilise Fmoc-Nle-OH to synthesise peptides with specific modifications, aiding in the investigation of biological pathways and molecular interactions. Its defined structure makes it suitable for creating labelled peptides or probes.
| Molecular weight | 353.41 |
|---|---|
| Empirical formula | C21H23NO4 |
| Assay | ≥98.0% (sum of enantiomers, HPLC) |
| Optical activity | [α]20/D −18±1°, c = 1% in DMF |
| Storage temperature | 2-8°C |
| Melting point | 141-144 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Nle-OH used for?
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Fmoc-Nle-OH is predominantly used as a protected amino acid building block in peptide synthesis and chemical biology research for creating modified peptides and unnatural amino acid structures.
What are the CAS number and formula for Fmoc-Nle-OH?
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The CAS number for Fmoc-Nle-OH is 77284-32-3, and its empirical formula is C21H23NO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-Nle-OH with a purity of ≥98.0% (sum of enantiomers, HPLC). This product is not represented as USP, BP, or EP grade.
How should Fmoc-Nle-OH be handled and stored?
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Handle Fmoc-Nle-OH with appropriate personal protective equipment, including eyeshields, gloves, and a type N95 respirator filter. Store the compound at 2-8°C.
Is Fmoc-Nle-OH a controlled substance?
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The provided data does not indicate that Fmoc-Nle-OH is a controlled substance.
How is this chemical packed and exported?
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Tech Serve Solutions, established in 1998, is a specialist global supplier and exporter of fine chemicals, adhering to stringent packaging and export regulations for safe and compliant international distribution.
How can I request a sample or quote for Fmoc-Nle-OH?
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Please contact our sales team directly through the TSS website or via phone to request a sample or obtain a quotation for Fmoc-Nle-OH.
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