Fmoc-β-Homothr(tBu)-OH
Fmoc-β-Homothr(tBu)-OH (CAS: 353245-99-5) is a protected unnatural amino acid derivative with the molecular formula C24H29NO5. This compound serves as a valuable building block in chemical synthesis, particularly within peptide chemistry and chemical biology research. Its structure incorporates the Fmoc protecting group for amine functionality and a tert-butyl ether for the hydroxyl group, facilitating controlled peptide elongation and modification in synthetic strategies.
- IUPAC
- (3R,4R)-4-tert-Butoxy-3-(Fmoc-amino)pentanoic acid,Fmoc-O-tert-butyl-L-β-homothreonine
Peptide Synthesis
Fmoc-β-Homothr(tBu)-OH is employed in solid-phase and solution-phase peptide synthesis. The Fmoc group allows for facile deprotection under mild basic conditions, while the tert-butyl ether protects the hydroxyl side chain during coupling reactions.
Chemical Biology Research
As an unnatural amino acid derivative, it can be incorporated into peptides to study their structure-activity relationships, conformational preferences, or to introduce specific functionalities for biochemical probes.
Drug Discovery and Development
This compound can be utilized in the synthesis of novel peptidomimetics or modified peptides with potential therapeutic applications, contributing to the development of new drug candidates.
Organic Synthesis
Beyond peptide chemistry, Fmoc-β-Homothr(tBu)-OH can serve as a chiral synthon in complex organic synthesis, leveraging its defined stereochemistry and functional groups for constructing intricate molecular architectures.
| Molecular weight | 411.49 |
|---|---|
| Empirical formula | C24H29NO5 |
| Assay | ≥96.0% (HPLC) |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-β-Homothr(tBu)-OH used for?
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Fmoc-β-Homothr(tBu)-OH is primarily used as a building block in peptide synthesis, chemical biology, and organic synthesis for creating modified peptides and complex molecules.
What are the CAS number and molecular formula for Fmoc-β-Homothr(tBu)-OH?
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The CAS number for Fmoc-β-Homothr(tBu)-OH is 353245-99-5, and its molecular formula is C24H29NO5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-β-Homothr(tBu)-OH with a purity of ≥96.0% (HPLC). We do not represent this product as USP, BP, or EP grade.
How should Fmoc-β-Homothr(tBu)-OH be handled and stored?
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Handle Fmoc-β-Homothr(tBu)-OH with appropriate personal protective equipment, including eyeshields and gloves. Store the chemical at 2-8°C to maintain its stability and integrity.
Is Fmoc-β-Homothr(tBu)-OH a controlled substance?
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Based on the provided data, Fmoc-β-Homothr(tBu)-OH is not listed as a controlled substance. Its WGK Germany classification is 3.
How is Fmoc-β-Homothr(tBu)-OH shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, handling the packing and export of products like Fmoc-β-Homothr(tBu)-OH in compliance with international regulations.
How can I request a sample or quote for Fmoc-β-Homothr(tBu)-OH?
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To request a sample or quote for Fmoc-β-Homothr(tBu)-OH, please contact our sales team through the TSS website or your designated account manager.
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