Fmoc-β-Homoarg(Pmc)-OH
Fmoc-β-Homoarg(Pmc)-OH (CAS: 700377-76-0) is an unnatural amino acid derivative with the empirical formula C36H44N4O7S and a molecular weight of 676.82. This compound is a valuable building block in chemical synthesis, particularly within peptide chemistry and chemical biology. Its structure allows for the introduction of modified amino acid residues into peptide chains, facilitating the study of protein structure-function relationships and the development of novel peptidomimetics.
- IUPAC
- Nβ-Fmoc-Nω-(2,2,5,7,8-pentamethylchromane-6-sulfonyl)-L-β-homoarginine
Peptide Synthesis
Fmoc-β-Homoarg(Pmc)-OH serves as a specialised building block in solid-phase peptide synthesis (SPPS). Its Fmoc protection strategy is compatible with standard SPPS protocols, enabling the incorporation of a beta-homoarginine residue with a Pmc protecting group on the side chain.
Chemical Biology Research
This unnatural amino acid derivative is employed in chemical biology to investigate the role of modified amino acids in biological systems. It can be incorporated into peptides or proteins to study altered conformational properties, binding affinities, or biological activities.
Drug Discovery and Development
As a synthetic intermediate, Fmoc-β-Homoarg(Pmc)-OH is utilised in the design and synthesis of novel therapeutic agents. Its unique structure can contribute to the development of peptidomimetics with enhanced stability, bioavailability, or target specificity.
Unnatural Amino Acid Libraries
This compound is a key component in the creation of unnatural amino acid libraries, which are essential tools for exploring diverse chemical space and discovering peptides with novel functions or properties.
| Molecular weight | 676.82 |
|---|---|
| Empirical formula | C36H44N4O7S |
| Assay | ≥95.0% (HPLC) |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-β-Homoarg(Pmc)-OH used for?
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Fmoc-β-Homoarg(Pmc)-OH is primarily used as a specialised building block in peptide synthesis, chemical biology research, and drug discovery. It allows for the incorporation of modified beta-homoarginine residues into peptides and peptidomimetics.
What is the CAS number and empirical formula for Fmoc-β-Homoarg(Pmc)-OH?
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The CAS number for Fmoc-β-Homoarg(Pmc)-OH is 700377-76-0, and its empirical formula is C36H44N4O7S.
What grade and purity does Tech Serve Solutions supply for Fmoc-β-Homoarg(Pmc)-OH?
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Tech Serve Solutions supplies Fmoc-β-Homoarg(Pmc)-OH with an assay of ≥95.0% (HPLC). This product is intended for research and chemical synthesis purposes and is not represented as USP, BP, EP, or other pharmacopoeial grades.
What are the safety considerations when handling Fmoc-β-Homoarg(Pmc)-OH?
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When handling Fmoc-β-Homoarg(Pmc)-OH, it is essential to use appropriate personal protective equipment, including eyeshields and gloves. A respirator filter (type N95 or P1) may be necessary. The substance has a WGK Germany classification of 3, indicating a potential hazard to water.
How is Fmoc-β-Homoarg(Pmc)-OH stored and shipped?
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Fmoc-β-Homoarg(Pmc)-OH should be stored at 2-8°C. It is securely packed and exported by Tech Serve Solutions, adhering to all relevant shipping regulations for chemical compounds.
How can I request a sample or quote for Fmoc-β-Homoarg(Pmc)-OH?
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To request a sample or a quote for Fmoc-β-Homoarg(Pmc)-OH, please contact the Tech Serve Solutions sales team through our website or by phone. Provide the product name and CAS number for prompt service.
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