Oligomycin A

CAS 579-13-5C45H74O11Biochemicals & Reagents

Oligomycin A (CAS: 579-13-5), with the molecular formula C45H74O11 and a molecular weight of 791.06 g/mol, is a potent antibiotic. It functions by inhibiting mitochondrial ATP synthase, thereby disrupting cellular energy production. This compound is valuable in biochemical research for studying oxidative phosphorylation, membrane-bound enzymes, and cellular respiration.

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Oligomycin A (C45H74O11) — chemical structure, CAS 579-13-5; Life Science, fine chemical supplied by Tech Serve Solutions

AntibioticsAntibiotics A to ZAntibiotics N-SAntibiotics by ApplicationAntifungalBiochemicals and ReagentsChemical Structure ClassInhibits an EnzymeMacrolidesMechanism of Action

01 /Applications

Mitochondrial ATP Synthase Inhibition

Oligomycin A is widely employed to inhibit the F1F0-ATPase complex, specifically targeting the mitochondrial ATP synthase. This action is crucial for research into cellular respiration and energy metabolism pathways.

Biochemical Research Tool

It serves as a key reagent in studies investigating oxidative phosphorylation, proton translocation across membranes, and the mechanism of antibiotic action in various biological systems.

Studying Sucrose Synthesis and Translocation

Oligomycin A has been utilized in plant physiology research to inhibit sucrose synthesis and investigate the translocation of 14C in plant tissues, such as sunflower leaves.

Carotid Chemoreceptor Studies

The compound has been used in physiological research to examine the responses of carotid chemoreceptors to variations in oxygen and carbon dioxide levels in animal models.

02 /Properties

Molecular weight	791.06
Empirical formula	C45H74O11
Assay	≥95% (HPLC)
Storage temperature	−20°C
Application	Oligomycin is used to inhibit membrane bount mitochondrial ATP synthase. It is used to inhibit sucrose synthesis and 14C translocation in sunflower leaves, to study antibiotic resistance, and to study carotid chemoreceptor responses to O2 and CO2 in the cat 1,2.

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H302Harmful if swallowed

Protective equipment	dust mask type N95 (US), Eyeshields, Gloves
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xn
Risk statements (R)	22

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

579-13-5

MDL number

MFCD00065705

Beilstein registry

5702132

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Oligomycin A used for?

Oligomycin A is used to inhibit mitochondrial ATP synthase, and in research applications for studying sucrose synthesis, 14C translocation, antibiotic resistance, and carotid chemoreceptor responses.

What are the CAS number and formula for Oligomycin A?

The CAS number for Oligomycin A is 579-13-5 and its empirical formula is C45H74O11.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Oligomycin A with a purity of ≥95% (HPLC). This product is intended for laboratory and research use and is not represented as USP, BP, EP, or any other pharmacopoeial grade.

How should Oligomycin A be handled safely?

Oligomycin A is harmful if swallowed (H302). When handling, use a dust mask type N95 (US), eyeshields, and gloves. Store in a cool, dry place, preferably at -20°C.