Fmoc-β-Glu(OtBu)-OH
Fmoc-β-Glu(OtBu)-OH (CAS: 209252-17-5), a protected beta-amino acid derivative with the formula C24H27NO6 and a molecular weight of 425.47 g/mol, is a key building block in peptide synthesis. This compound facilitates the incorporation of unnatural beta-amino acids into peptide chains, enabling the development of novel peptidomimetics and modified peptides with unique structural and functional properties for chemical biology and synthesis.
- IUPAC
- Fmoc-L-β-glutamic acid 5-tert-butyl ester,Fmoc-L-β-homoaspartic acid 5-tert-butyl ester
Peptide Synthesis
Fmoc-β-Glu(OtBu)-OH is utilised as a crucial building block in solid-phase and solution-phase peptide synthesis. Its Fmoc protecting group allows for orthogonal deprotection strategies, while the tert-butyl ester protects the side chain carboxyl group.
Chemical Biology Research
This unnatural amino acid derivative enables researchers to introduce beta-glutamic acid residues into peptides, creating modified peptides for studying protein structure, function, and interactions. It is instrumental in designing peptidomimetics with altered stability or receptor binding.
Drug Discovery and Development
The incorporation of beta-amino acids can lead to peptides with enhanced resistance to enzymatic degradation and improved pharmacokinetic profiles. Fmoc-β-Glu(OtBu)-OH serves as a valuable intermediate in the synthesis of novel therapeutic peptides.
Materials Science
Peptides containing unnatural amino acids can self-assemble into ordered nanostructures. Fmoc-β-Glu(OtBu)-OH can be employed in the synthesis of peptide-based biomaterials with tailored properties for various applications.
| Molecular weight | 425.47 |
|---|---|
| Empirical formula | C24H27NO6 |
| Assay | ≥98.0% (HPLC) |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-β-Glu(OtBu)-OH used for?
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Fmoc-β-Glu(OtBu)-OH is primarily used as a protected building block in peptide synthesis, enabling the incorporation of unnatural beta-amino acids into peptide chains for applications in chemical biology, drug discovery, and materials science.
What are the CAS number and formula for Fmoc-β-Glu(OtBu)-OH?
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The CAS number for Fmoc-β-Glu(OtBu)-OH is 209252-17-5, and its empirical formula is C24H27NO6.
What grade and purity does Tech Serve Solutions supply for Fmoc-β-Glu(OtBu)-OH?
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Tech Serve Solutions supplies Fmoc-β-Glu(OtBu)-OH with a purity of ≥98.0% as determined by HPLC. This is a research grade chemical and is not supplied as USP, BP, or EP grade.
What are the safety and handling recommendations for Fmoc-β-Glu(OtBu)-OH?
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Handle Fmoc-β-Glu(OtBu)-OH with appropriate personal protective equipment, including eyeshields and gloves. In environments where dust or aerosols may be generated, use a type N95 (US) or type P1 (EN143) respirator filter. It has a WGK rating of 3 in Germany, indicating a high hazard to water.
How is Fmoc-β-Glu(OtBu)-OH stored and shipped?
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Fmoc-β-Glu(OtBu)-OH should be stored at 2-8°C. Tech Serve Solutions ensures proper packaging and handling for safe export and shipping of this chemical.
How can I request a sample or quote for Fmoc-β-Glu(OtBu)-OH?
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To request a sample or a quote for Fmoc-β-Glu(OtBu)-OH, please contact our sales team through the website or by phone, providing your specific requirements and delivery details.
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