Fmoc-Gln(Trt)-OH
Fmoc-Gln(Trt)-OH (CAS: 132327-80-1) is a protected amino acid derivative with the empirical formula C39H34N2O5 and a molecular weight of 610.70 g/mol. This compound is primarily utilised in solid-phase peptide synthesis (SPPS) and solution-phase synthesis. Its Nα-Fmoc and Nδ-trityl protecting groups facilitate controlled peptide chain elongation, making it a crucial building block in the creation of complex peptides and peptidomimetics for research and development.
- IUPAC
- Nα-Fmoc-Nδ-trityl-L-glutamine
Peptide Synthesis
Fmoc-Gln(Trt)-OH is extensively used in Fmoc/tBu solid-phase peptide synthesis (SPPS) and solution-phase strategies. The trityl (Trt) group on the glutamine side chain provides robust protection during coupling steps, while the Nα-Fmoc group allows for facile deprotection and chain extension.
Chemical Biology Research
As a protected glutamine derivative, this compound is instrumental in constructing peptides with specific sequences for studying protein-protein interactions, enzyme mechanisms, and developing novel therapeutic peptides. Its controlled incorporation allows for precise structural modifications.
Organic Synthesis
Beyond peptide synthesis, Fmoc-Gln(Trt)-OH can serve as a chiral building block in the synthesis of complex organic molecules, particularly those requiring the introduction of a protected glutamine residue or related functionalities.
| Molecular weight | 610.70 |
|---|---|
| Empirical formula | C39H34N2O5 |
| Assay | ≥98.0% (HPLC) |
| Optical activity | [α]/D -14.0±1.5°, c = 1% in DMF |
| Storage temperature | 2-8°C |
Hazard statements
- H317May cause an allergic skin reaction
- H413May cause long-lasting harmful effects to aquatic life
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 43-53 |
| Safety statements (S) | 24-37-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Gln(Trt)-OH used for?
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Fmoc-Gln(Trt)-OH is primarily used as a protected building block in solid-phase and solution-phase peptide synthesis, facilitating the controlled assembly of peptide chains for research in chemical biology and drug discovery.
What are the CAS number and formula for Fmoc-Gln(Trt)-OH?
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The CAS number for Fmoc-Gln(Trt)-OH is 132327-80-1, and its empirical formula is C39H34N2O5.
What grade and purity does Tech Serve Solutions supply for Fmoc-Gln(Trt)-OH?
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Tech Serve Solutions supplies Fmoc-Gln(Trt)-OH with an assay of ≥98.0% (HPLC). We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should Fmoc-Gln(Trt)-OH be handled safely?
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Fmoc-Gln(Trt)-OH is classified as a GHS07 substance with a warning signal word. It may cause an allergic skin reaction (H317) and may cause long lasting harmful effects to aquatic life (H413). Appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator filter, should be used during handling.
How is Fmoc-Gln(Trt)-OH packed and exported by TSS?
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Fmoc-Gln(Trt)-OH is typically stored at 2-8°C. As a specialist global supplier and exporter, Tech Serve Solutions ensures appropriate packaging and adherence to all regulations for the export of fine chemicals.
How can I request a quote or sample for Fmoc-Gln(Trt)-OH?
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To request a quote or a sample of Fmoc-Gln(Trt)-OH, please contact our sales team through the website or by phone, providing your specific requirements.
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