Fmoc-Gln(Trt)-OPfp
Fmoc-Gln(Trt)-OPfp (CAS: 132388-65-9) is a specialised chemical featuring the Fmoc protecting group for Nα-amino protection and the Trityl group for Nγ-protection of L-glutamine, with a pentafluorophenyl ester leaving group. This derivative is crucial for solid-phase peptide synthesis, enabling controlled peptide chain elongation. Its structure facilitates specific coupling reactions in the development of peptides and peptidomimetics.
- IUPAC
- Nα-Fmoc-Nγ-trityl-L-glutamine pentafluorophenyl ester
- Synonyms
- Nα-Fmoc-Nγ-trityl-L-glutamine pentafluorophenyl ester
Solid-Phase Peptide Synthesis (SPPS)
Fmoc-Gln(Trt)-OPfp is widely employed in SPPS for the sequential introduction of glutamine residues into peptide chains. The orthogonal protection strategy allows for selective deprotection and coupling steps, ensuring high fidelity in peptide synthesis.
Peptide Library Synthesis
This reagent is valuable for constructing diverse peptide libraries used in drug discovery and biochemical research. Its reliable reactivity facilitates the synthesis of complex peptides with defined sequences and side-chain modifications.
Chemical Biology Research
In chemical biology, Fmoc-Gln(Trt)-OPfp aids in synthesising peptides for studying protein-protein interactions, enzyme mechanisms, and as building blocks for peptidomimetics with potential therapeutic applications.
Organic Synthesis
Beyond peptides, the activated ester functionality can be utilised in specific organic synthesis pathways where controlled acylation with a protected glutamine derivative is required.
| Molecular weight | 776.75 |
|---|---|
| Empirical formula | C45H33F5N2O5 |
| Assay | ≥97.0% |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Gln(Trt)-OPfp used for?
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Fmoc-Gln(Trt)-OPfp is primarily used in solid-phase peptide synthesis (SPPS) for the controlled incorporation of Nα-Fmoc-Nγ-trityl-L-glutamine into peptide sequences. It is also applied in peptide library synthesis and chemical biology research.
What are the CAS number and formula for Fmoc-Gln(Trt)-OPfp?
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The CAS number is 132388-65-9, and the empirical formula is C45H33F5N2O5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-Gln(Trt)-OPfp with an assay of ≥97.0%. This is a research-grade chemical and is not represented as USP, BP, or EP.
How should Fmoc-Gln(Trt)-OPfp be handled and stored?
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Handle Fmoc-Gln(Trt)-OPfp with appropriate personal protective equipment, including eyeshields and gloves. Use a type N95 (US) or P1 (EN143) respirator filter if necessary. Store at 2-8°C to maintain stability.
Is Fmoc-Gln(Trt)-OPfp a controlled substance?
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The provided data does not indicate that Fmoc-Gln(Trt)-OPfp is a controlled substance.
How is Fmoc-Gln(Trt)-OPfp typically packed and exported?
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Fmoc-Gln(Trt)-OPfp is carefully packaged to ensure stability during transit and is exported globally by Tech Serve Solutions in compliance with international shipping regulations for fine chemicals.
How can I request a sample or quote for Fmoc-Gln(Trt)-OPfp?
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Please contact our sales department via the website or direct email to request a sample or a formal quotation for Fmoc-Gln(Trt)-OPfp.
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