Fmoc-D-propargyl-Gly-OH
Fmoc-D-propargyl-Gly-OH (CAS: 220497-98-3), with the molecular formula C20H17NO4 and a molecular weight of 335.35, is an unnatural amino acid derivative. This compound serves as a valuable building block in chemical synthesis, particularly within peptide chemistry and chemical biology. Its structure incorporates a protected amine group (Fmoc) and a propargyl side chain, enabling versatile conjugation and modification strategies in research and development settings.
- IUPAC
- (R)-2-(Fmoc-amino)-4-pentynoic acid,Fmoc-D-2-propargylglycine
Peptide Synthesis
Fmoc-D-propargyl-Gly-OH is used as a non-canonical amino acid in solid-phase peptide synthesis (SPPS) to introduce a clickable alkyne moiety into peptide chains. This facilitates post-synthetic modification via click chemistry.
Chemical Biology Probes
The alkyne functionality allows for the facile labeling of biomolecules, peptides, or proteins with fluorescent dyes, affinity tags, or other functional groups using copper-catalyzed alkyne-azide cycloaddition (CuAAC) or strain-promoted alkyne-azide cycloaddition (SPAAC).
Drug Discovery
This unnatural amino acid can be incorporated into peptidomimetics or small molecule libraries to explore structure-activity relationships (SAR) and develop novel therapeutic agents.
Bioconjugation
Its ability to participate in click chemistry makes it useful for creating bioconjugates, such as antibody-drug conjugates (ADCs) or peptide-based drug delivery systems, by linking molecules with high specificity and efficiency.
| Molecular weight | 335.35 |
|---|---|
| Empirical formula | C20H17NO4 |
| Assay | ≥96.0% (HPLC) |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-D-propargyl-Gly-OH used for?
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Fmoc-D-propargyl-Gly-OH is primarily used in peptide synthesis, for the creation of chemical biology probes, in drug discovery research, and for bioconjugation applications, owing to its unnatural amino acid structure with a protected amine and an alkyne side chain.
What is the CAS number and formula for Fmoc-D-propargyl-Gly-OH?
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The CAS number for Fmoc-D-propargyl-Gly-OH is 220497-98-3, and its molecular formula is C20H17NO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-D-propargyl-Gly-OH with an assay of ≥96.0% (HPLC). TSS does not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should Fmoc-D-propargyl-Gly-OH be handled and stored?
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Handling requires appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator (type N95 or P1). Store at 2-8°C to maintain compound integrity. The compound has a WGK Germany rating of 3.
Is Fmoc-D-propargyl-Gly-OH a controlled substance?
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The provided data does not indicate that Fmoc-D-propargyl-Gly-OH is a controlled substance.
How are Tech Serve Solutions' chemicals packed, shipped, and exported?
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Tech Serve Solutions offers expert packing, shipping, and global export services for fine chemicals, pharmaceutical intermediates, and laboratory reagents, adhering to all relevant international regulations.
How can I request a sample or quote for Fmoc-D-propargyl-Gly-OH?
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To request a sample or a quotation, please contact the Tech Serve Solutions sales team through our website or by phone.
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