Fluoro-N,N,N′,N′-bis(tetramethylene)formamidinium hexafluorophosphate
Fluoro-N,N,N′,N′-bis(tetramethylene)formamidinium hexafluorophosphate (CAS: 164298-25-3), a white crystalline solid, serves as a valuable reagent in chemical synthesis, particularly for the preparation of immonium-type coupling reagents. With a molecular weight of 316.20 g/mol and an assay of ≥99.0%, this compound is suitable for advanced research and development applications. It is stored under refrigeration at 2-8°C to maintain its stability and reactivity for demanding chemical transformations.
- IUPAC
- BTFFH,Fluoro-dipyrrolidinocarbenium hexafluorophosphate
- Synonyms
- N′-bis(tetramethylene)formamidinium hexafluorophosphateC9H16F7N2PBTFFHFluoro-dipyrrolidinocarbenium hexafluorophosphate

Synthesis of Coupling Reagents
This compound acts as a key reagent in the synthesis of immonium-type coupling reagents. These reagents are crucial for facilitating the formation of amide bonds and other critical linkages in organic synthesis.
Peptide Chemistry
It finds application in peptide chemistry for the activation of carboxylic acids, enabling efficient peptide bond formation. Its use can contribute to the streamlined synthesis of complex peptide sequences.
Chemical Synthesis Intermediate
As a versatile synthetic reagent, it can be employed in various organic transformations. Its specific structure allows for unique reactivity profiles in the construction of complex molecules.
| Molecular weight | 316.20 |
|---|---|
| Empirical formula | C9H16F7N2P |
| Assay | ≥99.0% (T) |
| Storage temperature | 2-8°C |
| Application | Reagent for synthesis of immonium-type coupling reagents1 |
| Melting point | 154-160 °C |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fluoro-N,N,N′,N′-bis(tetramethylene)formamidinium hexafluorophosphate used for?
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Fluoro-N,N,N′,N′-bis(tetramethylene)formamidinium hexafluorophosphate is primarily used as a reagent for the synthesis of immonium-type coupling reagents, with applications extending to peptide chemistry and general chemical synthesis.
What are the CAS number and molecular formula for this compound?
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The CAS number is 164298-25-3, and the empirical formula is C9H16F7N2P.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of ≥99.0% (T). We do not represent this product as meeting USP, BP, or EP pharmacopoeia standards.
How should Fluoro-N,N,N′,N′-bis(tetramethylene)formamidinium hexafluorophosphate be handled safely?
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This compound is a Warning substance with hazards H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Handle with appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves. Ensure adequate ventilation.
How is this chemical shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. Specific shipping and export details for Fluoro-N,N,N′,N′-bis(tetramethylene)formamidinium hexafluorophosphate will be provided upon inquiry, adhering to all relevant regulations.
How can I request a sample or a quote?
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To request a sample or a quote for Fluoro-N,N,N′,N′-bis(tetramethylene)formamidinium hexafluorophosphate, please contact our sales department through the website or by phone.
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