(2-Bromoethyl) chloroformate
(2-Bromoethyl) chloroformate (CAS 4801-27-8) is a reactive organic compound with the linear formula ClCOOCH2CH2Br and a molecular weight of 187.42 g/mol. It serves as a valuable reagent in organic synthesis, particularly for protection and derivatization strategies in chemical biology and peptide chemistry. This compound is essential for introducing specific functional groups in complex molecular structures.
Amine Protection
(2-Bromoethyl) chloroformate is frequently employed for the protection of amine groups in organic synthesis. It reacts with amines to form carbamates, which can be selectively removed under specific conditions, facilitating multi-step syntheses.
Peptide Synthesis
In peptide chemistry, this reagent can be utilised for the modification and protection of amino acid residues. Its bifunctional nature allows for the introduction of specific linking groups or protecting functionalities crucial for solid-phase or solution-phase peptide synthesis.
Chemical Biology Reagent
As a versatile chemical biology tool, (2-Bromoethyl) chloroformate is used for labelling and derivatizing biomolecules. Its reactivity allows for the conjugation of molecules, enabling studies in biological systems and drug discovery.
Synthetic Intermediate
This compound acts as a key intermediate in the synthesis of more complex organic molecules. Its chloro- and bromoethyl functionalities provide reactive sites for various coupling and substitution reactions in the development of pharmaceuticals and fine chemicals.
| Molecular weight | 187.42 |
|---|---|
| Linear formula | ClCOOCH2CH2Br |
| Assay | 90% |
| Grade | technical grade |
| Density | 1.749 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.478(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 62 °C / 143.6 °F |
| Transport (UN / ADR) | UN 3277 6.1/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (2-Bromoethyl) chloroformate used for?
+
(2-Bromoethyl) chloroformate is primarily used as a reagent in organic synthesis for amine protection, derivatization, and as an intermediate in the synthesis of peptides and other complex organic molecules within chemical biology and synthetic chemistry.
What are the CAS number and formula for (2-Bromoethyl) chloroformate?
+
The CAS number for (2-Bromoethyl) chloroformate is 4801-27-8, and its linear formula is ClCOOCH2CH2Br.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies (2-Bromoethyl) chloroformate as a technical grade material with an assay of 90%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should (2-Bromoethyl) chloroformate be handled safely?
+
(2-Bromoethyl) chloroformate is a corrosive substance that causes severe skin burns and eye damage (H314). Handle with extreme care, wearing full protective equipment including faceshields, gloves, and appropriate respiratory protection. Ensure good ventilation. Refer to the Safety Data Sheet for detailed handling instructions.
How is (2-Bromoethyl) chloroformate packed and shipped?
+
(2-Bromoethyl) chloroformate is packed in compliance with transport regulations for hazardous materials, such as UN 3277, Class 6.1. It is suitable for export globally by Tech Serve Solutions.
How can I request a sample or quote for (2-Bromoethyl) chloroformate?
+
To request a sample or a quotation for (2-Bromoethyl) chloroformate, please contact our sales department through the website or by direct inquiry, providing your specific requirements.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis