(2-Bromoethoxy)-tert-butyldimethylsilane

CAS 86864-60-0BrCH2CH2OSi(CH3)2C(CH3)3Chemical Synthesis

(2-Bromoethoxy)-tert-butyldimethylsilane (CAS: 86864-60-0) is a brominated organosilicon compound with the linear formula BrCH2CH2OSi(CH3)2C(CH3)3 and a molecular weight of 239.23 g/mol. It serves as a valuable reagent in organic synthesis, particularly for introducing the tert-butyldimethylsilyl (TBS) protected hydroxyethyl group. This compound is instrumental in protection/deprotection strategies and in the synthesis of complex organic molecules.

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(2-Bromoethoxy)-tert-butyldimethylsilane (BrCH2CH2OSi(CH3)2C(CH3)3) — chemical structure, CAS 86864-60-0; Chemistry, fine chemical supplied by Tech Serve Solutions

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01 /Applications

TBSO-Ethyl Group Introduction

Utilised as a reagent for the introduction of the TBSO-ethyl group, enabling selective protection of hydroxyl functionalities in organic synthesis.

N-Protection Strategy

Functions as a reagent for N-protection, facilitating subsequent synthetic transformations by masking amine groups.

Synthesis of N-Acetic Acids

Treatment with Jones reagent leads to hydrolysis and oxidation, yielding N-acetic acids for further synthetic elaborations.

02 /Properties

Molecular weight	239.23
Linear formula	BrCH2CH2OSi(CH3)2C(CH3)3
Assay	99%
Boiling point	70-75 °C/2.5 mmHg(lit.)
Density	1.115 g/mL at 25 °C(lit.)
Refractive index	n20/D 1.444(lit.)
Contains / stabiliser	Na2CO3 as stabilizer
Application	Reagent for N-protection with the TBSO-ethyl group. Treatment with Jones reagent effects hydrolysis and concomitant oxidation leading to N-acetic acids for further synthetic elaboration.

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P305IF IN EYES

Flash point	73 °C / 163.4 °F
Transport (UN / ADR)	NA 1993 / PGIII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xi
Risk statements (R)	36/37/38
Safety statements (S)	26

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

86864-60-0

MDL number

MFCD00209550

PubChem substance

24866813

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is (2-Bromoethoxy)-tert-butyldimethylsilane primarily used for?

This compound is primarily used as a reagent for N-protection with the TBSO-ethyl group. Treatment with Jones reagent effects hydrolysis and concomitant oxidation, leading to N-acetic acids for further synthetic elaboration.

What is the CAS number and molecular formula for (2-Bromoethoxy)-tert-butyldimethylsilane?

The CAS number is 86864-60-0 and the linear molecular formula is BrCH2CH2OSi(CH3)2C(CH3)3.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies (2-Bromoethoxy)-tert-butyldimethylsilane with an assay of 99%. We do not represent this product as USP, BP, EP, or any other pharmacopoeial grade.

What are the safety and handling considerations for this product?

(2-Bromoethoxy)-tert-butyldimethylsilane is a Warning substance classified with H315 (causes skin irritation), H319 (causes serious eye irritation), and H335 (may cause respiratory irritation). Handle with appropriate personal protective equipment in a well-ventilated area. Refer to the Safety Data Sheet for detailed information.