Fluoroacetonitrile
Fluoroacetonitrile (CAS: 503-20-8; Formula: FCH2CN; MW: 59.04 g/mol) is a versatile fluorinated building block. This colourless liquid is primarily employed in organic synthesis for the introduction of the fluoromethylnitrile moiety into various molecules. Its reactivity makes it a valuable intermediate in the development of novel organic compounds within research and industrial chemical processes.
Synthesis of Heterocyclic Compounds
Fluoroacetonitrile serves as a precursor in the preparation of heterocyclic compounds such as 2-fluoromethyl-4,4,6-trimethyl-1,3-oxazine. This demonstrates its utility in constructing complex ring systems.
Preparation of Fluorinated Ketones
The compound is utilised in the synthesis of alpha-fluorinated acetophenone derivatives. This application highlights its role in introducing fluorine atoms adjacent to carbonyl groups.
Intermediate for Amino Acid Derivatives
Fluoroacetonitrile is a key intermediate in the synthesis of compounds like 2-amino-2-fluoromethyl-3-pentenenitrile, which is further elaborated into 2,5-diamino-2-fluoromethyl-3(E)-pentenoic acid.
| Molecular weight | 59.04 |
|---|---|
| Linear formula | FCH2CN |
| Assay | 98% |
| Boiling point | 79-80 °C(lit.) |
| Density | 1.061 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.333(lit.) |
| Application | Fluoroacetonitrile has been used in preparation of:• 2-fluoromethyl-4,4,6-trimethyl-1,3-oxazine1• α-fluorinated acetophenone2• 2-amino-2-fluoromethyl-3-pentenenitrile, a key intermediate in the synthesis of 2,5-diamino-2-fluoromethyl-3(E)-pentenoic acid3 |
Hazard statements
- H225Highly flammable liquid and vapour
- H301Toxic if swallowed
- H311Toxic in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H331Toxic if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
- P311Call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -14 °C / 6.8 °F |
| Transport (UN / ADR) | UN 3273 3/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,T |
| Risk statements (R) | 11-23/24/25-36/37/38 |
| Safety statements (S) | 16-26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fluoroacetonitrile used for?
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Fluoroacetonitrile is primarily used as a building block in organic synthesis for preparing fluorinated compounds, including heterocyclic systems, ketones, and amino acid derivatives.
What are the CAS number and chemical formula for Fluoroacetonitrile?
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The CAS number for Fluoroacetonitrile is 503-20-8, and its chemical formula is FCH2CN.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fluoroacetonitrile with a purity of 98%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated.
How should Fluoroacetonitrile be handled safely?
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Fluoroacetonitrile is a highly flammable liquid and vapour (H225), and is toxic if swallowed, in contact with skin, or if inhaled (H301, H311, H331). It can also cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Always handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, in a well-ventilated area.
Does TSS export Fluoroacetonitrile?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including Fluoroacetonitrile.
How can I request a quote or sample for Fluoroacetonitrile?
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To request a quote or a sample of Fluoroacetonitrile, please contact our sales team through the website or by calling us directly.
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