Perfluorooctanoic acid
Perfluorooctanoic acid (CAS 335-67-1), with the linear formula CF3(CF2)6COOH and a molecular weight of 414.07 g/mol, is a synthetic perfluorinated carboxylic acid. It is recognised for its unique chemical properties stemming from the strong carbon-fluorine bonds. Utilised primarily in chemical synthesis and specialty applications, it serves as a building block or precursor in various fluorinated processes, including fluorous synthesis and the preparation of Rf-tagged compounds.
- IUPAC
- PFOA,Pentadecafluorooctanoic acid,Perfluorocaprylic acid,Perfluorooctanoic acid
- Synonyms
- Perfluorocaprylic acidPentadecafluorooctanoic acidPFOA

Chemical Synthesis
Perfluorooctanoic acid serves as a key intermediate or reagent in the synthesis of complex organic molecules. Its fluorinated nature allows for unique reactivity and product properties.
Fluorous Synthesis
This compound is employed in fluorous phase synthesis techniques, enabling selective extraction and purification of reaction products due to the distinct solubility of fluorinated compounds.
Rf-Tagged Building Blocks
It acts as a precursor for creating Rf-tagged building blocks, which are valuable tools in medicinal chemistry and material science for tracing and purification.
Specialty Fluorochemicals
Perfluorooctanoic acid is used in the production of various specialty fluorochemicals and materials where high stability and specific surface properties are required.
| Molecular weight | 414.07 |
|---|---|
| Linear formula | CF3(CF2)6COOH |
| Assay | 96% |
| Boiling point | 189 °C/736 mmHg(lit.) |
| Melting point | 55-56 °C(lit.) |


Hazard statements
- H302Harmful if swallowed
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGIII |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | C |
| Risk statements (R) | 22-34-52/53 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Perfluorooctanoic acid used for?
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Perfluorooctanoic acid is used in chemical synthesis, fluorous synthesis, as a precursor for Rf-tagged building blocks, and in the production of specialty fluorochemicals.
What is the CAS number and formula for Perfluorooctanoic acid?
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The CAS number is 335-67-1 and the linear formula is CF3(CF2)6COOH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Perfluorooctanoic acid with an assay of 96%. We do not represent this product as USP, BP, or EP grade.
How should Perfluorooctanoic acid be handled safely?
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Perfluorooctanoic acid is corrosive and harmful if swallowed. Handle with appropriate personal protective equipment, including eyeshields, face shields, gloves, and respiratory protection (e.g., N100 respirator). Ensure adequate ventilation and avoid contact with skin and eyes.
Is Perfluorooctanoic acid a controlled substance?
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The provided data does not indicate that Perfluorooctanoic acid is a controlled substance.
How is Perfluorooctanoic acid shipped and exported?
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Perfluorooctanoic acid is shipped as UN 3261, Class 8, Packing Group III. Tech Serve Solutions is experienced in global export procedures for chemicals.
How can I request a quote or sample?
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To request a quote or sample, please contact our sales team through the website or by phone, referencing the product name and CAS number 335-67-1.
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