Aconitine
Aconitine (CAS: 302-27-2), with the molecular formula C34H47NO11 and a molecular weight of 645.74 g/mol, is a potent neurotoxin. It functions by activating tetrodotoxin-sensitive Na+ channels, leading to presynaptic depolarization and a blockade of neurotransmitter release. Aconitine also inhibits norepinephrine reuptake and is known to induce ventricular tachycardia. This compound is primarily utilised in research settings for its specific ion channel modulatory properties.
- IUPAC
- Acetylbenzoylaconine
Neuroscience Research
Aconitine is used in electrophysiology studies to investigate the function and modulation of voltage-gated sodium channels. Its ability to activate these channels makes it a valuable tool for understanding neuronal excitability and neurotransmission.
Ion Channel Studies
As a modulator of monovalent ion channels, particularly sodium channels, aconitine aids researchers in exploring the mechanisms of cellular signaling and membrane potential regulation. Its specific action on tetrodotoxin-sensitive channels is key in these investigations.
Pharmacological Research Tool
This compound serves as a pharmacological probe to study the effects of sodium channel activation and norepinephrine reuptake inhibition. Researchers utilise aconitine to understand complex physiological processes and potential therapeutic targets.
| Molecular weight | 645.74 |
|---|---|
| Empirical formula | C34H47NO11 |
| Assay | ≥95% (HPLC) |
| Form | crystalline |
| Colour | white |
| Solubility | H2O: soluble0.3 mg/mLethanol: soluble35 mg/mL |
| Application | Aconitine is a neurotoxin which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization and blocking the release of neurotransmitters. Aconitine also blocks norepinephrine reuptake. In the heart, aconitine induces ventricular tachycardia after intracoronary injection. |
Hazard statements
- H300Fatal if swallowed
- H330Fatal if inhaled
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P264Wash thoroughly after handling
- P284Wear respiratory protection
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 1544 6.1/PG 1 |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 26/28 |
| Safety statements (S) | 24-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Aconitine used for?
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Aconitine (CAS: 302-27-2, Formula: C34H47NO11) is primarily used as a research tool in neuroscience and ion channel studies due to its potent neurotoxic and ion channel modulatory properties, particularly its activation of tetrodotoxin-sensitive Na+ channels.
What are the CAS number and formula for Aconitine?
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The CAS number for Aconitine is 302-27-2, and its molecular formula is C34H47NO11.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Aconitine with a purity of ≥95% (HPLC). This product is intended for research and laboratory use and is not represented as USP, BP, EP, or pharmacopoeia grade.
How should Aconitine be handled safely?
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Aconitine is highly toxic (Danger; H300, H330). Handling requires stringent safety precautions, including the use of appropriate personal protective equipment such as eyeshields, face shields, chemical-resistant gloves, and a P3 or N100 respirator. Work should be conducted in a well-ventilated area or fume hood.
How is Aconitine packed, shipped, and exported?
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Aconitine is carefully packed according to international shipping regulations for hazardous materials (UN 1544, Class 6.1, Packing Group I). Tech Serve Solutions has extensive experience in exporting chemicals globally, ensuring compliant and secure delivery.
How can I request a sample or quote for Aconitine?
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To request a sample or a quotation for Aconitine, please contact our sales department through the website or by calling us directly. Please provide your required quantity and shipping details.
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