Adapalene
Adapalene (CAS: 106685-40-9), with the chemical formula C28H28O3 and a molecular weight of 412.52, is a topical retinoid analogue. It acts as a RARβ and RARγ agonist. In vitro studies indicate Adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells. It is also an established and efficacious topical treatment for acne vulgaris.
- IUPAC
- 6-(4-Methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid,6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic acid,CD-271,Differin
- Synonyms
- 6-(4-Methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic acidCD-271Differin
Acne Vulgaris Treatment
Adapalene is widely recognised for its efficacy as a topical treatment for acne vulgaris. It helps to normalise theeseen follicular keratinisation process.
Cancer Cell Research
In vitro research demonstrates that Adapalene can inhibit proliferation and induce apoptosis in certain colorectal cancer cells. It is a valuable tool for studying retinoid mechanisms in cancer biology.
Retinoid Receptor Agonist Studies
As a selective agonist for RARβ and RARγ receptors, Adapalene is employed in research to investigate the specific roles and signalling pathways associated with these nuclear receptors.
| Molecular weight | 412.52 |
|---|---|
| Empirical formula | C28H28O3 |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | white to off-white |
| Solubility | DMSO: >10 mg/mL |
| Storage temperature | 2-8°C |
| Application | Adapalene, a retinoic acid analogue, is a RARβ and RARγ agonist. Adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro. Adapalene gel is an efficacious treatment for acne vulgaris. |
| Storage Condition | desiccated |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Adapalene used for?
+
Adapalene is used as a topical treatment for acne vulgaris and in vitro research for studying cancer cell proliferation and retinoid receptor agonism.
What is the CAS number and formula for Adapalene?
+
The CAS number for Adapalene is 106685-40-9, and its chemical formula is C28H28O3.
What grade and purity does Tech Serve Solutions supply for Adapalene?
+
Tech Serve Solutions supplies Adapalene with a purity of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade.
How should Adapalene be handled and stored?
+
Adapalene is a white to off-white powder. It should be stored at 2-8°C in a desiccated state. Consult the Safety Data Sheet for detailed handling and hazard information.
How is Adapalene packed, shipped, and exported?
+
Adapalene is carefully packed to ensure stability and integrity during transit. Tech Serve Solutions is an experienced global supplier and exporter of fine chemicals.
How can I request a quote or sample of Adapalene?
+
To request a quote or sample of Adapalene, please contact our sales team through the website or by phone.
▶ Related products
(−)-Curcumol
C15H24O2
Cell Biology
(±) Clopidogrel hydrogensulfate
Cell Biology
(±)-L-Alliin
C6H11NO3S
Cell Biology
(±)-2-Amino-4-phosphonobutyric acid
C4H10NO5P
Cell Biology
(±)-2-Methylarachidonoyl-2′-fluoroethylamide
C23H38NOF
Cell Biology
(±)-3,4-Methylenedioxy-N-ethylamphetamine hydrochloride
Cell Biology
(±)-3,4-Methylenedioxyamphetamine hydrochloride
Cell Biology
(±)-3,4-Methylenedioxymethamphetamine hydrochloride
Cell Biology
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis