Adefovir

CAS 106941-25-7C8H12N5O4PCell Biology

Adefovir (CAS: 106941-25-7; Formula: C8H12N5O4P; MW: 273.19 g/mol) is a synthetic acyclic phosphonate nucleoside analogue. Primarily recognised for its antiviral properties, it functions as a potent inhibitor of viral DNA polymerases. This compound is extensively utilised in research settings, particularly in the study of viral replication mechanisms and the development of novel antiviral therapeutics for conditions such as HIV and Hepatitis B.

IUPAC: GS 0393,GS-393,P-[[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosphonic acid, 9-(2-phosphonylmethoxyethyl)adenine,PMEA
Synonyms: PMEA9-(2-phosphonylmethoxyethyl)adenineP-[[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosphonic acid

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Adefovir (C8H12N5O4P) — chemical structure, CAS 106941-25-7; Life Science, fine chemical supplied by Tech Serve Solutions

A-AMBioactive Small MoleculesCell Biology

01 /Applications

Antiviral Research

Adefovir is a key reagent in virology research, specifically for investigating the replication cycles of DNA and RNA viruses. Its mechanism of action as a viral polymerase inhibitor makes it valuable for studying drug resistance and developing new antiviral agents.

Biochemical Studies

As a bioactive small molecule, Adefovir is employed in biochemical assays to probe cellular pathways related to nucleotide metabolism and DNA synthesis. It serves as a tool for understanding enzyme kinetics and cellular responses to nucleoside analogues.

Cell Biology Investigations

Researchers utilize Adefovir to study its effects on cell proliferation and viability in various cell lines. Its role in interfering with DNA replication allows for investigations into cellular stress responses and apoptosis pathways.

02 /Properties

Molecular weight	273.19
Empirical formula	C8H12N5O4P
Assay	≥98% (HPLC)
Form	powder
Colour	white to beige
Solubility	0.1 M NaOH: ≥5 mg/mL
Storage temperature	−20°C

03 /Safety & handling

GHS hazard pictogram: Toxic (GHS06) — Toxic

Danger

Hazard statements

H301Toxic if swallowed

Precautionary statements

P301IF SWALLOWED

Transport (UN / ADR)	UN 2811 6.1 / PGIII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	T
Risk statements (R)	25
Safety statements (S)	45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

106941-25-7

05 /Additional specifications

Storage Condition	desiccated

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Adefovir used for?

Adefovir is primarily used in research for its antiviral properties, particularly in studying HIV and Hepatitis B viral replication, and as a tool in biochemical and cell biology investigations.

What is the CAS number and formula for Adefovir?

The CAS number for Adefovir is 106941-25-7, and its empirical formula is C8H12N5O4P.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Adefovir with a purity of ≥98% (HPLC). TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade.

How should Adefovir be handled safely?

Adefovir is classified as acutely toxic if swallowed (H301) and requires careful handling. Wear appropriate personal protective equipment, including gloves and eye protection, and handle in a well-ventilated area or fume hood. Avoid ingestion, inhalation, and skin contact. Refer to the Safety Data Sheet for comprehensive handling instructions.

How is Adefovir packed and shipped?

Adefovir is typically supplied as a white to beige powder and shipped according to its hazard classification (UN 2811 6.1 / PGIII). Storage is recommended at -20°C in a desiccated environment.