1,3-Dioxane
1,3-Dioxane (CAS 505-22-6) is a cyclic acetal with the empirical formula C4H8O2 and a molecular weight of 88.11 g/mol. This organic compound serves as a valuable building block in chemical synthesis. It is primarily utilised as a solvent, notably in the creation of medium-ring systems such as dioxazocines and dioxazonines, contributing to advancements in synthetic organic chemistry.
- IUPAC
- Formaldehyde trimethylene acetal
- Synonyms
- Formaldehyde trimethylene acetal1,3-Dioxacyclohexane
Solvent in Macrocycle Synthesis
1,3-Dioxane acts as a solvent in the synthesis of 8- and 9-membered dioxazocines and dioxazonines. Its properties facilitate the cyclisation reactions required for forming these complex ring structures.
Organic Building Block
As a cyclic acetal, 1,3-Dioxane functions as a versatile building block in organic synthesis. It can be incorporated into larger molecular frameworks or used to introduce specific functional groups.
Chemical Synthesis
This compound is employed in various chemical synthesis pathways, contributing to the development of novel organic molecules. Its utility spans diverse research and development applications within chemistry.
| Molecular weight | 88.11 |
|---|---|
| Empirical formula | C4H8O2 |
| Assay | ≥98.0% (GC) |
| Boiling point | 105-106 °C(lit.) |
| Density | 1.032 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.418(lit.)n20/D 1.419 |
| Application | 1,3-Dioxane has been employed as solvent in the synthesis of 8- and 9-membered dioxazocines and dioxazonines1. |
| Melting point | −45 °C(lit.) |
Hazard statements
- H225Highly flammable liquid and vapour
- H302Harmful if swallowed
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P280Wear protective gloves, clothing and eye/face protection
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 5 °C / 41 °F |
| Transport (UN / ADR) | UN 1165 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-20/21/22 |
| Safety statements (S) | 16 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1,3-Dioxane primarily used for?
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1,3-Dioxane is primarily used as a solvent in the synthesis of 8- and 9-membered dioxazocines and dioxazonines, and as a building block in general organic synthesis.
What is the CAS number and formula for 1,3-Dioxane?
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The CAS number for 1,3-Dioxane is 505-22-6, and its empirical formula is C4H8O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1,3-Dioxane with an assay of ≥98.0% (GC). We do not represent this product as USP, BP, or EP grade.
What are the main hazards associated with 1,3-Dioxane?
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1,3-Dioxane is a highly flammable liquid and vapour (H225) and is harmful if swallowed, in contact with skin, or if inhaled (H302 + H312 + H332). Appropriate personal protective equipment, including eyeshields, gloves, and suitable respiratory protection, should be used during handling.
How is 1,3-Dioxane packed, shipped, and exported?
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1,3-Dioxane is carefully packed according to international shipping regulations for flammable liquids (UN 1165, Class 3, PG II). We handle all aspects of export for our global clientele.
How can I request a quote or sample?
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To request a quote or a sample of 1,3-Dioxane, please contact our sales team through the website or call us directly. We are happy to assist with your specific requirements.
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