3,4-Dichlorophenylboronic acid
3,4-Dichlorophenylboronic acid (CAS 151169-75-4), with a molecular weight of 190.82, is a vital organoboronic acid derivative. It functions as a key reactant in crucial organic synthesis pathways, notably in Suzuki coupling reactions. This compound also serves as a precursor in the development of diverse biologically active molecules, including potential therapeutic agents for various conditions.
- IUPAC
- 3,4-Dichlorobenzeneboronic acid
- Synonyms
- 3,4-Dichlorobenzeneboronic acid
Suzuki Coupling Reactions
3,4-Dichlorophenylboronic acid is frequently employed as a coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the formation of carbon-carbon bonds for complex molecule synthesis.
Synthesis of Biologically Active Molecules
This boronic acid is a valuable building block in the multi-step synthesis of various biologically relevant compounds, such as inhibitors of Mycobacterium tuberculosis chorismate mutase and pyrrole derivatives.
Precursor for Novel Compounds
It acts as a key intermediate in the preparation of diverse chemical entities including nitrovinyl biphenyls with anticancer potential and pyrazolopyrimidines exhibiting inhibitory activity against specific enzymes.
| Molecular weight | 190.82 |
|---|---|
| Linear formula | Cl2C6H3B(OH)2 |
| Application | Reactant involved in:• Lithiation/borylation-protodeboronation of homoallyl carbamates1• Suzuki coupling reactions2,3Precursor / reactant involved in synthesis of biologically active molecules including:• Mycobacterium tuberculosis H37Rv chorismate mutase inhibitors2• Pyrrole derivatives as PDE4B inhibitors3• Nitrovinyl biphenyls as anticancer agents4• Dual immunosuppressive and anti-inflammatory agents5• Pyrazolopyrimidines as Cryptosporidium and Toxoplasma CDPK1 inhibitors6 |
| Melting point | 280-285 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3,4-Dichlorophenylboronic acid used for?
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3,4-Dichlorophenylboronic acid is primarily used as a reactant in Suzuki coupling reactions and as a precursor in the synthesis of biologically active molecules, including potential therapeutic agents.
What is the CAS number and formula for 3,4-Dichlorophenylboronic acid?
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The CAS number for 3,4-Dichlorophenylboronic acid is 151169-75-4, and its linear formula is Cl2C6H3B(OH)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3,4-Dichlorophenylboronic acid typically as a research or technical grade. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated otherwise in the product documentation.
How should 3,4-Dichlorophenylboronic acid be handled safely?
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3,4-Dichlorophenylboronic acid is classified as an irritant. Handle with appropriate personal protective equipment, including a dust mask (N95 or equivalent), eyeshields, and gloves. Ensure adequate ventilation and avoid breathing dust. In case of contact, follow standard first aid procedures as indicated by the hazard statements (H315, H319, H335).
Is 3,4-Dichlorophenylboronic acid a controlled substance?
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Based on the provided data, 3,4-Dichlorophenylboronic acid is not listed as a controlled substance.
How is this chemical packed and exported?
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Tech Serve Solutions securely packs and exports fine chemicals globally, adhering to all relevant shipping regulations to ensure safe delivery.
How can I request a sample or quote for 3,4-Dichlorophenylboronic acid?
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Please contact our sales department via the website or directly via email/phone to request a sample or a quotation for 3,4-Dichlorophenylboronic acid.
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