Chlorotripyrrolidinophosphonium hexafluorophosphate
Chlorotripyrrolidinophosphonium hexafluorophosphate (CAS: 133894-48-1; Formula: C12H24ClN3P · PF6) is a chemical reagent with a molecular weight of 421.73. It is primarily utilised in peptide coupling reactions and the synthesis of various coupling and condensing reagents. Its applications extend to sequence-selective peptide recognition and the development of heterocyclic β-sheet ligands, making it a valuable compound in peptide chemistry and broader chemical synthesis.
- IUPAC
- PyCloP

Peptide Coupling Reagent
This compound serves as a reagent in peptide coupling reactions, facilitating the formation of amide bonds essential for peptide synthesis. It is also used in the synthesis of other coupling reagents.
Peptide Recognition Studies
Its properties allow for its use in sequence-selective peptide recognition, aiding in the study and understanding of peptide interactions.
Synthesis of Heterocyclic Ligands
Chlorotripyrrolidinophosphonium hexafluorophosphate is employed in the synthesis of heterocyclic β-sheet ligands, contributing to the development of novel chemical structures.
Chemical Synthesis
As a versatile synthetic reagent, it finds application in various chemical synthesis pathways beyond peptide chemistry, including the creation of condensing reagents.
| Molecular weight | 421.73 |
|---|---|
| Linear formula | C12H24ClN3P · PF6 |
| Assay | ≥98.0% (AT) |
| Storage temperature | 2-8°C |
| Application | Reagent for: Peptide coupling reactions1,2 and synthesis of coupling reagents3 Sequence selective peptide recognition4 Synthesis of condensing reagents5 Synthesis of heterocyclic β-sheet ligands6 |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 1759 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Chlorotripyrrolidinophosphonium hexafluorophosphate used for?
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Chlorotripyrrolidinophosphonium hexafluorophosphate is used as a reagent in peptide coupling reactions and the synthesis of coupling and condensing reagents. It is also applied in sequence-selective peptide recognition and the synthesis of heterocyclic β-sheet ligands.
What are the CAS number and formula for this compound?
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The CAS number is 133894-48-1, and the chemical formula is C12H24ClN3P · PF6.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product with an assay of ≥98.0% (AT). We do not represent it as USP, BP, or EP grade.
How should Chlorotripyrrolidinophosphonium hexafluorophosphate be handled safely?
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This compound causes severe skin burns and eye damage (H314). Handling requires appropriate personal protective equipment, including eyeshields, face shields, and chemically resistant gloves. Ensure adequate ventilation and use a suitable respirator. Store at 2-8°C.
How is this chemical shipped and exported?
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This chemical is shipped as a UN 1759, Hazard Class 8, Packing Group II. Tech Serve Solutions is experienced in global export procedures for fine chemicals.
How can I request a quote or sample?
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To request a quote or sample, please contact our sales team through the TSS website or by calling our customer service line.
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