Calcium Ionophore A23187 hemimagnesium salt
Calcium Ionophore A23187 hemimagnesium salt (CAS 72124-77-7, C29H36Mg0.5N3O6) is a highly selective calcium ionophore with a molecular weight of 534.77. This compound is instrumental in cell biology and signalling research, enabling the study of intracellular calcium dynamics. It potentiates responses to NMDA and stimulates nitric oxide production, making it valuable for investigating mitochondrial function and apoptosis.
- IUPAC
- A23187 hemimagnesium salt,Antibiotic A 23187 hemimagnesium salt,Calcimycin hemimagnesium salt,Calimycin hemimagnesium salt
- Synonyms
- A23187 hemimagnesium saltAntibiotic A 23187 hemimagnesium saltCalcimycin hemimagnesium saltCalimycin hemimagnesium salt
Calcium Signalling Research
As a potent calcium ionophore, A23187 hemimagnesium salt is used to investigate the role of intracellular calcium in various cellular processes, including neurotransmission and cell death pathways.
Nitric Oxide Production Studies
This compound stimulates nitric oxide production via calmodulin-dependent constitutive nitric oxide synthase, facilitating research into cellular signalling mechanisms.
Mitochondrial Function Analysis
It is employed to study the effects of elevated intracellular calcium concentrations on mitochondrial bioenergetics and intrinsic apoptosis.
NMDA Receptor Potentiation
Calcium Ionophore A23187 hemimagnesium salt has been shown to potentiate responses mediated by NMDA receptors in biological systems.
| Molecular weight | 534.77 |
|---|---|
| Empirical formula | C29H36Mg0.5N3O6 |
| Storage temperature | 2-8°C |
| Application | Ionophore highly selective for Ca2+. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase. Used to study effects of elevated intracellular calcium on mitochondrial function and intrinsic apoptosis. |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Calcium Ionophore A23187 hemimagnesium salt used for?
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Calcium Ionophore A23187 hemimagnesium salt is primarily used in research to study intracellular calcium signalling, nitric oxide production, mitochondrial function, and apoptosis. It acts as a highly selective ionophore for Ca2+.
What is the CAS number and chemical formula?
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The CAS number is 72124-77-7, and the empirical formula is C29H36Mg0.5N3O6.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical for research purposes. The specific assay and purity are detailed in the product specifications. We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should Calcium Ionophore A23187 hemimagnesium salt be handled safely?
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This compound is harmful if swallowed, in contact with skin, or if inhaled, and causes skin and eye irritation. Appropriate personal protective equipment, including eyeshields, gloves, and a dust mask (type N95 or equivalent), should be worn. Work should be conducted in a well-ventilated area.
Is Calcium Ionophore A23187 hemimagnesium salt packed, shipped, or exported globally?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including Calcium Ionophore A23187 hemimagnesium salt. Please contact us for specific shipping and export information.
How can I request a sample or quote?
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To request a sample or a quote, please contact our sales team through the provided channels on our website.
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