Calyculin A from Discodermia calyx

CAS 101932-71-2C50H81N4O15PBiochemicals & Reagents

Calyculin A (CAS: 101932-71-2), with the molecular formula C50H81N4O15P and a molecular weight of 1009.17 g/mol, is a potent inhibitor of serine/threonine protein phosphatases, notably Protein Phosphatase 1 (PP1). This bioactive small molecule is isolated from the marine sponge Discodermia calyx. Its primary applications lie in biochemical research, particularly in cell signalling studies and as a tool for investigating cellular processes regulated by protein dephosphorylation.

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Calyculin A from Discodermia calyx (C50H81N4O15P) — chemical structure, CAS 101932-71-2; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesBiochemicals and ReagentsC-CHCancer ResearchCell BiologyEnzyme InhibitorsEnzyme Inhibitors by EnzymeEnzymesInhibitorsand Substrates

01 /Applications

Protein Phosphatase Inhibition

Calyculin A is a highly specific inhibitor of Protein Phosphatase 1 (PP1) and Protein Phosphatase 2A (PP2A). It is widely used in research to explore the roles of these phosphatases in various cellular pathways.

Cell Signalling Research

Due to its ability to modulate protein dephosphorylation, Calyculin A is a valuable reagent for studying signal transduction pathways. It helps researchers understand how cellular responses are controlled by the balance of phosphorylation and dephosphorylation events.

Cancer Research Tool

As a potent phosphatase inhibitor, Calyculin A can influence cell cycle progression and apoptosis. This makes it a useful tool for investigating mechanisms relevant to cancer biology and developing new therapeutic strategies.

Biochemical Assays

The compound serves as a standard in biochemical assays designed to screen for or study phosphatase activity and inhibition. Its well-defined inhibitory profile aids in the validation and characterisation of enzymatic processes.

02 /Properties

Molecular weight	1009.17
Empirical formula	C50H81N4O15P
Assay	≥90% (HPLC)
Form	solid
Colour	white
Solubility	DMSO: solubleethanol: soluble
Storage temperature	−20°C

03 /Safety & handling

GHS hazard pictogram: Toxic (GHS06) — Toxic

Danger

Hazard statements

H301Toxic if swallowed
H315Causes skin irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P280Wear protective gloves, clothing and eye/face protection
P301IF SWALLOWED
P311Call a POISON CENTER or doctor

Protective equipment	Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Transport (UN / ADR)	UN 3462 6.1 / PGIII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	T
Risk statements (R)	23/24/25-38
Safety statements (S)	36/37/39-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

101932-71-2

MDL number

MFCD06795864

PubChem substance

24892795

Beilstein registry

4903216

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Calyculin A used for?

Calyculin A is primarily used as a research tool for its potent inhibition of protein phosphatases, particularly PP1 and PP2A. It is applied in studies of cell signalling, cell biology, cancer research, and biochemical assays.

What are the CAS number and formula for Calyculin A?

The CAS number for Calyculin A is 101932-71-2, and its molecular formula is C50H81N4O15P.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Calyculin A with an assay of ≥90% (HPLC). This product is intended for research purposes and is not represented as USP, BP, EP, or any other pharmacopoeial grade.

How should Calyculin A be handled safely?

Calyculin A is classified as Danger, with hazards including acute toxicity and skin irritation (H301 + H311 + H331-H315). Appropriate personal protective equipment, including eyeshields, faceshields, gloves, and P2 respirator cartridges, must be used. Handle in a well-ventilated area.

Is Calyculin A a controlled substance?

The provided data does not indicate that Calyculin A is a controlled substance.

How is Calyculin A packed, shipped, and exported?

Calyculin A is supplied as a solid, typically white in colour, and stored at -20°C. TSS offers global export services for this chemical, adhering to all relevant shipping regulations, including UN 3462 classification.

How can I request a sample or quote for Calyculin A?

To request a sample or obtain a quote for Calyculin A, please contact our sales department through the website or via direct inquiry, providing your specific requirements.