Candesartan cilexetil

CAS 145040-37-5C33H34N6O6Biochemicals & Reagents

Candesartan cilexetil (CAS: 145040-37-5) is a white to beige powder with the molecular formula C33H34N6O6 and a molecular weight of 610.66. This compound acts as an Angiotensin II Receptor Blocker (ARB), primarily used in cardiovascular therapies. It is a key ingredient in medications designed to manage hypertension and heart failure by preventing the constriction of blood vessels. Candesartan cilexetil is a valuable reagent for research in pharmacology and drug development.

IUPAC: 2-ethoxy-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-Benzimidazole-7-carboxylic acid 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester,TCV 116,TCY 116

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Candesartan cilexetil (C33H34N6O6) — chemical structure, CAS 145040-37-5; Life Science, fine chemical supplied by Tech Serve Solutions

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01 /Applications

Hypertension Management

Candesartan cilexetil is a well-established therapeutic agent used in the treatment of high blood pressure. It functions by blocking the action of angiotensin II, a hormone that narrows blood vessels, thereby lowering blood pressure and reducing strain on the heart.

Heart Failure Therapy

Beyond hypertension, Candesartan cilexetil is also prescribed for patients with heart failure. By reducing vascular resistance and decreasing the workload on the heart, it helps improve symptoms and enhance cardiac function in individuals with compromised cardiovascular systems.

Pharmacological Research

As a specific Angiotensin II Receptor Blocker, Candesartan cilexetil serves as a critical tool in pharmacological research. It is used to investigate the renin-angiotensin-aldosterone system (RAAS) and to develop new therapeutic strategies for cardiovascular diseases.

Drug Discovery and Development

This compound is utilized in drug discovery programs aimed at identifying novel modulators of the renin-angiotensin system. Its availability as a high-purity chemical reagent facilitates preclinical studies and the assessment of potential new drug candidates.

02 /Properties

Molecular weight	610.66
Empirical formula	C33H34N6O6
Assay	≥98% (HPLC)
Form	powder
Colour	white to beige
Solubility	DMSO: ≥15 mg/mL
Storage temperature	2-8°C

03 /Safety & handling

GHS hazard pictogram: Health hazard (GHS08) — Health hazard

GHS hazard pictogram: Environmental hazard (GHS09) — Environmental hazard

Warning

Hazard statements

H361Suspected of damaging fertility or the unborn child
H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment
P281Use personal protective equipment as required

Transport (UN / ADR)	UN 3077 9 / PGIII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	T,N
Risk statements (R)	61-48/20-50
Safety statements (S)	53-45-61

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

145040-37-5

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Candesartan cilexetil used for?

Candesartan cilexetil is primarily used for the management of hypertension (high blood pressure) and heart failure. It is also employed in pharmacological research related to the renin-angiotensin system.

What are the CAS number and chemical formula for Candesartan cilexetil?

The CAS number for Candesartan cilexetil is 145040-37-5, and its chemical formula is C33H34N6O6.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Candesartan cilexetil with a purity of ≥98% (HPLC). This product is intended for research and laboratory use and is not represented as USP, BP, EP, or any other pharmacopoeia grade.

How should Candesartan cilexetil be handled and stored?

Candesartan cilexetil is classified as a Warning substance (GHS08, GHS09) with hazards including H361 (Suspected of damaging fertility or the unborn child) and H400 (Very toxic to aquatic life). It requires careful handling, including the use of appropriate personal protective equipment, and should be stored at 2-8°C, away from incompatible materials. Users must consult the Safety Data Sheet (SDS) before handling.

Is Candesartan cilexetil a controlled substance?

The provided data does not indicate that Candesartan cilexetil is a controlled substance.

How is Candesartan cilexetil packed and shipped?

Candesartan cilexetil is supplied as a white to beige powder. Shipping and handling comply with relevant regulations, including UN 3077 for transport. For specific packaging and export details, please contact TSS.

How can I request a sample or quote for Candesartan cilexetil?

To request a sample or a quotation for Candesartan cilexetil, please contact our sales department via the website or by phone. Our team will be happy to assist you with your inquiry.