Calcium Ionophore A23187 hemicalcium salt
Calcium Ionophore A23187 hemicalcium salt (CAS: 59450-89-4, C29H36Ca0.5N3O6) is a highly selective ionophore for Ca2+. This yellow powder, with a molecular weight of 542.65, is soluble in DMSO and ethanol. It is widely utilized in cell biology research to study calcium signaling pathways, potentiate responses to certain neurotransmitters, and stimulate nitric oxide production in cell culture.
- IUPAC
- A23187 hemicalcium salt,Antibiotic A 23187 hemicalcium salt,Calcimycin hemicalcium salt,Calimycin hemicalcium salt
- Synonyms
- Calcimycin hemicalcium saltCalimycin hemicalcium saltAntibiotic A23187 hemicalcium salt
Calcium Ion Transport
As a selective ionophore, Calcium Ionophore A23187 hemicalcium salt facilitates the transport of Ca2+ across biological membranes. This property makes it invaluable for investigating intracellular calcium dynamics and its role in cellular signaling.
Neuroscience Research
This compound potentiates responses to N-methyl-D-aspartate (NMDA) receptors, making it a useful tool in neuroscience for studying neuronal excitability and synaptic plasticity.
Stimulation of Nitric Oxide Production
In cell culture applications, Calcium Ionophore A23187 hemicalcium salt has been shown to stimulate nitric oxide production via the calmodulin-dependent constitutive nitric oxide synthase.
Cell Biology Studies
Its ability to modulate intracellular calcium levels makes it a key reagent for a variety of cell biology studies, including investigations into apoptosis, cell proliferation, and signal transduction pathways.
| Molecular weight | 542.65 |
|---|---|
| Empirical formula | C29H36Ca0.5N3O6 |
| Form | powder |
| Colour | yellow |
| Solubility | DMSO: solubleethanol: soluble |
| Storage temperature | 2-8°C |
| Application | Ionophore highly selective for Ca2+. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase. |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Calcium Ionophore A23187 hemicalcium salt used for?
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Calcium Ionophore A23187 hemicalcium salt is used as an ionophore highly selective for Ca2+ in research applications. It is employed to study calcium signaling, potentiate responses to NMDA receptors, and stimulate nitric oxide production in cell culture.
What are the CAS number and molecular formula?
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The CAS number is 59450-89-4 and the molecular formula is C29H36Ca0.5N3O6.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical for research and laboratory use. We do not represent this product as meeting USP, BP, EP, or any other pharmacopoeia standards. Please refer to the Certificate of Analysis for specific purity information.
How should Calcium Ionophore A23187 hemicalcium salt be handled?
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Handle with appropriate personal protective equipment, including a dust mask (type N95 or equivalent), eyeshields, and gloves. Avoid breathing dust and ensure adequate ventilation. This compound is classified with GHS07 hazard symbols, indicating it is a warning substance.
Is Calcium Ionophore A23187 hemicalcium salt packed, shipped, or exported by TSS?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including Calcium Ionophore A23187 hemicalcium salt.
How can I request a sample or quote?
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To request a sample or a quote for Calcium Ionophore A23187 hemicalcium salt, please contact our sales department through the website or by phone.
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