Bromotripyrrolidinophosphonium hexafluorophosphate
Bromotripyrrolidinophosphonium hexafluorophosphate (CAS: 132705-51-2; C12H24BrF6N3P2) is a phosphonium-based coupling reagent with a molecular weight of 466.18. It is primarily employed as a catalyst in various synthetic organic chemistry applications. Key uses include the synthesis of primary amides, direct dehydrative cross-coupling reactions, direct arylation, and pyrrolidide formation, making it a versatile tool for chemical synthesis and peptide chemistry.
- IUPAC
- PyBroP®
Amide Synthesis
This compound serves as an effective catalyst for the synthesis of primary amides from corresponding carboxylic acids and amines, facilitating amide bond formation under dehydrative conditions.
Dehydrative Cross-Coupling
It catalyses direct dehydrative phosphonium cross-coupling reactions, enabling the formation of new bonds by eliminating water molecules and forming a covalent linkage.
Direct Arylation
Bromotripyrrolidinophosphonium hexafluorophosphate is utilised as a reagent in direct arylation processes, a method for introducing aryl groups into organic molecules.
Pyrrolidide Formation
It is employed in the formation of pyrrolidides through coupling reactions, offering a specific pathway for the synthesis of these cyclic amide derivatives.
| Molecular weight | 466.18 |
|---|---|
| Empirical formula | C12H24BrF6N3P2 |
| Assay | ≥95.0% (HPLC) |
| Storage temperature | −20°C |
| Application | Catalyst for: Synthesis of primary amides1 Direct dehydrative phosphonium cross coupling2 Direct arylation3 Pyrrolidide formation by phosphonium salt coupling reagents4 |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Bromotripyrrolidinophosphonium hexafluorophosphate used for?
+
Bromotripyrrolidinophosphonium hexafluorophosphate is used as a catalyst and reagent in organic synthesis, notably for the preparation of primary amides, direct dehydrative cross-coupling reactions, direct arylation, and pyrrolidide formation.
What are the CAS number and chemical formula for Bromotripyrrolidinophosphonium hexafluorophosphate?
+
The CAS number is 132705-51-2, and the chemical formula is C12H24BrF6N3P2.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies Bromotripyrrolidinophosphonium hexafluorophosphate with an assay of ≥95.0% (HPLC). TSS does not represent this product as USP, BP, EP, or any pharmacopoeial grade.
How should Bromotripyrrolidinophosphonium hexafluorophosphate be handled safely?
+
This compound is classified as corrosive (GHS05, Danger) and causes severe skin burns and eye damage (H314). Handle with appropriate personal protective equipment, including a dust mask (type N95), eyeshields, and gloves. Ensure adequate ventilation and follow safety protocols for corrosive substances.
How is Bromotripyrrolidinophosphonium hexafluorophosphate shipped or exported?
+
Tech Serve Solutions specialises in the global supply and export of fine chemicals, adhering to all relevant shipping and export regulations for hazardous materials.
How can I request a sample or quote for Bromotripyrrolidinophosphonium hexafluorophosphate?
+
To request a sample or a quote, please contact the Tech Serve Solutions sales team through our website or by calling our office.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis