Bromotris(dimethylamino)phosphonium hexafluorophosphate
Bromotris(dimethylamino)phosphonium hexafluorophosphate (CAS: 50296-37-2) is a phosphonium salt with the formula BrP[N(CH3)2]3PF6 and a molecular weight of 388.07 g/mol. This chemical is primarily employed as a versatile reagent in organic synthesis. Its applications span conjugate additions, nucleoside modifications, asymmetric hydrogenations, and peptide coupling, demonstrating its utility across various chemical transformations.
- IUPAC
- BroP,Bromotris(N-methylmethanaminato)-phosphorus hexafluorophosphate
![Bromotris(dimethylamino)phosphonium hexafluorophosphate (BrP[N(CH3)2]3PF6) — chemical structure, CAS 50296-37-2; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F50296-37-2.png&w=3840&q=75)
Conjugate Addition Reactions
Serves as a reagent for the conjugate addition of nitroalkanes to acrylate equivalents, facilitating carbon-carbon bond formation in organic synthesis.
Peptide Synthesis
Utilised as a coupling reagent in peptide chemistry, aiding in the formation of peptide bonds for the synthesis of peptides and peptidomimetics.
Nucleoside Modification
Employed in a polymer-supported approach for the modification of nucleosides, offering a route for derivatisation in nucleic acid chemistry.
Asymmetric Hydrogenation
Functions as a reagent in asymmetric hydrogenation reactions, contributing to the stereoselective synthesis of chiral molecules.
Synthesis of Complex Molecules
Applied in the synthesis of specialised compounds, such as cyclic PNA-based compounds directed against HIV-1 TAR RNA, showcasing its role in advanced synthetic methodologies.
| Molecular weight | 388.07 |
|---|---|
| Linear formula | BrP[N(CH3)2]3PF6 |
| Assay | ≥98.0% (AT) |
| Application | Reagent for: Conjugate addition of nitroalkanes to an acrylate equivalent1 A novel polymer supported approach to nucleoside modification2 Asymmetric hydrogenations3 Peptide coupling4 Pyrrolidine hydroxylation5 Synthesis of cyclic PNA-based compound directed against HIV-1 TAR RNA6 |
| Melting point | >300 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
- H350May cause cancer
Precautionary statements
- P201Obtain special instructions before use
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3263 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 45-34 |
| Safety statements (S) | 53-26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Bromotris(dimethylamino)phosphonium hexafluorophosphate used for?
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Bromotris(dimethylamino)phosphonium hexafluorophosphate is used as a reagent in various organic synthesis applications, including conjugate addition of nitroalkanes, nucleoside modification, asymmetric hydrogenations, peptide coupling, and the synthesis of complex molecules like cyclic PNA compounds.
What are the CAS number and formula for Bromotris(dimethylamino)phosphonium hexafluorophosphate?
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The CAS number is 50296-37-2, and the chemical formula is BrP[N(CH3)2]3PF6.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound with an assay of ≥98.0% (AT). It is provided as a research-grade chemical and is not represented as USP, BP, EP, or any pharmacopoeia grade.
How should Bromotris(dimethylamino)phosphonium hexafluorophosphate be handled safely?
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This compound is classified as Danger (GHS05, GHS08) and causes severe skin burns and eye damage (H314), and may cause cancer (H350). Strict adherence to safety protocols is required, including the use of appropriate personal protective equipment such as eyeshields, face shields, specific respirator types, and protective gloves. Handle in a well-ventilated area or under a fume hood.
Is this chemical suitable for use in pharmaceutical manufacturing?
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While used in applications relevant to peptide chemistry and nucleoside modification, the supplied product is a research-grade chemical with an assay of ≥98.0% (AT). It is not supplied as USP, BP, or EP grade, and its suitability for direct pharmaceutical manufacturing depends on specific process validation and regulatory requirements.
How is this chemical shipped and exported?
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This product is shipped and exported under UN 3263, Hazard Class 8, Packing Group II, indicating it is a corrosive solid, acidic, inorganic, n.o.s. Packaging and transportation comply with relevant international regulations for hazardous materials.
How can I request a quote or sample?
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To request a quote or sample, please contact our sales department through the website or by phone, providing the product name and CAS number (50296-37-2) for prompt assistance.
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