Bromotrimethylsilane
Bromotrimethylsilane (CAS 2857-97-8), with the molecular formula (CH₃)₃SiBr and a molar mass of 153.09 g/mol, is a reactive organosilicon compound. It is primarily utilised as a reagent in organic synthesis, particularly in silicon-based chemistry. A key application involves its use with InCl₃ to catalyse the direct allylation of alcohols with allyltrimethylsilane. Its volatile and moisture-sensitive nature requires careful handling and storage.
- IUPAC
- TMBS,Trimethylbromosilane,Trimethylsilyl bromide
- Synonyms
- TMBSTrimethylbromosilaneTrimethylsilyl bromide
Catalysis in Allylation Reactions
Bromotrimethylsilane acts as a crucial component in catalysing the direct allylation of various alcohols. This process utilises indium(III) chloride (InCl₃) alongside allyltrimethylsilane, facilitating efficient carbon-carbon bond formation.
Protecting Group Chemistry
As a silicon-based reagent, it can be employed in the protection and derivatization of functional groups in complex organic molecules, particularly in multi-step syntheses.
Synthetic Reagent
Its reactive nature makes Bromotrimethylsilane a versatile reagent for introducing the trimethylsilyl group in various organic transformations, aiding in the synthesis of diverse chemical entities.
| Molecular weight | 153.09 |
|---|---|
| Linear formula | (CH3)3SiBr |
| Assay | ≥97.0% (AT) |
| Boiling point | 79 °C(lit.) |
| Density | 1.16 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.424(lit.)n20/D 1.424 |
| Storage temperature | 2-8°C |
| Contains / stabiliser | silver wool as stabilizer |
| Application | Used with InCl3 to catalyze the direct allylation of a variety of alcohols with allyltrimethylsilane.1 |
Hazard statements
- H226Flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 25 °C / 77 °F |
| Transport (UN / ADR) | UN 2920 3(8) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 10-14-34 |
| Safety statements (S) | 16-26-36/37/39-45 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Bromotrimethylsilane used for?
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Bromotrimethylsilane (CAS 2857-97-8) is used as a reagent in chemical synthesis, notably for catalysing the direct allylation of alcohols with allyltrimethylsilane in the presence of InCl₃, and in protecting group strategies.
What are the CAS number and formula for Bromotrimethylsilane?
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The CAS number for Bromotrimethylsilane is 2857-97-8, and its linear formula is (CH₃)₃SiBr.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Bromotrimethylsilane with an assay of ≥97.0% (AT). We do not represent this product as USP, BP, or EP grade.
How should Bromotrimethylsilane be handled safely?
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Bromotrimethylsilane is a dangerous substance (Danger) that is flammable (H226) and causes severe skin burns and eye damage (H314). It reacts violently with water. Appropriate personal protective equipment, including faceshields, gloves, and suitable respirators, must be used. Handle in a well-ventilated area away from ignition sources and water.
How is Bromotrimethylsilane packed and shipped?
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Bromotrimethylsilane is shipped as UN 2920, Hazard Class 3 (Flammable) with subsidiary hazard 8 (Corrosive), Packing Group II. It is stored at 2-8°C and contains silver wool as a stabilizer.
How can I request a sample or quote for Bromotrimethylsilane?
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Please contact our sales team via the website or direct email to request a sample or a quotation for Bromotrimethylsilane.
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